DOI QR코드

DOI QR Code

Protective Effects of Aged Ginger Extracts on Excessive Exercise-induced Stress

과도한 운동 스트레스에 대한 숙성생강 추출물의 방어효과

  • Received : 2020.12.15
  • Accepted : 2021.04.13
  • Published : 2021.08.01

Abstract

Ginger roots are widely used as spices in various foods and herbal medicine due to its characteristic flavor and biological activity. In this study, the protective effect of aged ginger extracts against oxidative stress were investigated using L6 muscle cells. As the results, aged ginger extracts significantly inhibited oxidative stress induced muscle cell damage. The protective effect of aged ginger extracts was higher than non-aged ginger extract. Aged ginger extracts also inhibited the increase in LDH, lactate and GOT in the mouse blood induced by excessive running exercise. Therefore, aged ginger is considered to be effective for protecting excessive exercise stress.

생강의 운동 스트레스에 대한 방어효과를 알아보기 위해 동결건조, 열풍건조, 숙성한 생강을 제조하여 추출물을 근육세포에 H2O2와 함께처리한 결과 생강을 숙성한 시료는 숙성하지 않은 시료에 비하여 우수한 근육세포 보호효과를 나타내었다. 또한 숙성생강 추출물을 마우스에 투여시 운동으로 인한 혈액내 LDH, lactate, GOT 증가를 억제시키는 경향을 나타내었다. 따라서 숙성생강을 섭취시 과도한 운동으로 인한 스트레스에 대한 방어효과를 기대할 수 있을 것으로 사료된다. 이러한 결과를 토대로, 향후 생강의 숙성 온도 및 시간에 따른 운동 스트레스 방어효과를 측정하여 가장 높은 활성을 나타내는 최적의 숙성 조건을 확립하는 연구를 진행할 예정이다.

Keywords

Acknowledgement

본 연구는 한국식품연구원 주요사업(E0210300-01) 및 농림기술개발사업의 지원에 의해 이루어졌습니다.

References

  1. Alessandro, P., P.P.L. Giuseppina, M. Francesca, Q. Alfredo, I. Giorgio and V. Cristina. 2015. Exercise and oxidative stress: Potential effects of antioxidant dietary strategies in sports. Nutrition 31:916-922. https://doi.org/10.1016/j.nut.2015.02.005
  2. Ali, B.H., G. Blunden, M.O. Tanira and A. Nemmar. 2008. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem. Toxicol. 46:409-420. https://doi.org/10.1016/j.fct.2007.09.085
  3. Berthoin, S., H. Allender, G. Baquet, G. Dupont, R. Matran, P. Pelayo and H. Robin. 2003. Plasma lactate and plasma volume recovery in adults and children following high-intensity exercises. Acta Paediatr. 92:283-290. https://doi.org/10.1111/j.1651-2227.2003.tb00547.x
  4. Brown, S.J., R.B. Child, S.H. Day and A.E. Donnelly. 1997. Indices of skeletal muscle damage and connective tissue breakdown following eccentric muscle contractions. Eur. J. Appl. Physiol. Occup. Physiol. 75:369-374. https://doi.org/10.1007/s004210050174
  5. Eo, H.J., G.H. Park, D.S. Kim, Y. Kang and Y. Park. 2020. Antioxidant and anticancer activities of leaves extracts from Acer tegmentosum. Korean J. Plant Res. 33:551-557. https://doi.org/10.7732/KJPR.2020.33.6.551
  6. Ha, M.S. and M.H. Rho. 2010. Effects of electroacupuncture on activity of GOT, GPT, LDH and functional recovery in the motor injury rats by the 6-hydroxydopamine. J. Korean Soc. Phys. Med. 5:265-272.
  7. Hyun, K.Y. 2009. An association of changed levels of inflammatory markers with hematological factors during one-time aerobic exercise in twenty-aged young men. J. Life Sci. 19:1658-1665. https://doi.org/10.5352/JLS.2009.19.11.1658
  8. James, E.S., L.G. Andre and S.C. Jeff. 2015. Exercise and cardiovascular risk in patients with hypertension. Am. J. Hypertens. 28:147-158. https://doi.org/10.1093/ajh/hpu191
  9. Jing, W., K., Weixin, B. Rui, H. Xiaosong and C. Fang. 2017. Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: A review. Ann. N. Y. Acad. Sci. 1398:83-98. https://doi.org/10.1111/nyas.13375
  10. Kim, C.H., K.D. Hahn and K.S. Park. 1996. Survey of rhizome rot incidence of ginger in major production areas in Korea. Kor. J. Plant Pathol. 12:336-344.
  11. Kim, H.H., S.J. Lee, Y.H. Chung, S.H. Kim and N.J. Sung. 2018. Physicochemical properties and antioxidant activities from hot-air and freeze dried aged black ginger (Zingiber officinale). J. Life Sci. 28:153-161. https://doi.org/10.5352/JLS.2018.28.2.153
  12. Kim, N.S., I.K. Jeong and C.H. Lee. 2010. Effect on promoting gastrointestinal function and inhibiting of decreasing body temperature of ginger extracts (Zingiber officinale). Korean J. Oriental Physiol. Pathol. 24:996-1003.
  13. Lee, E.J., S.A. Yang, H.D. Choi, H.G. Im, K. Whang and I.S. Lee. 2011. Comparison of gingerols in vrious fractions and the antioxidant effects of supercritical fluid extracts from ginger. Korean J. Food Sci. Technol. 43:469-474. https://doi.org/10.9721/KJFST.2011.43.4.469
  14. Lee, H.M., K.T. Kim and K.H. Lee. 2012. Quality characteristics of ginger (Zingiber officinale Roscoe) as the ripening periods. J. Fd. Hyg. Safety. 27:479-486. https://doi.org/10.13103/JFHS.2012.27.4.479
  15. Lee, S.J., J.H. Ryu, S.J. Nam and O.K. Koo. 2020. A study on the physicochemical properties and antioxidant activities of agedginger (Zingiber officinale Roscoe) during the aging process. Korean J. Food Sci. Technol. 52:573-579. https://doi.org/10.9721/KJFST.2020.52.6.573
  16. Muhammad, U.S., M.Y. Hadi, S. Aaqib and A.A.T. Asmaa. 2019. Impact of physical exercise on gut microbiome, inflammation, and the pathobiology of metabolic disorders. Rev. Diabet. Stud. 15:35-48. https://doi.org/10.1900/RDS.2019.15.35
  17. Rosalia, M.T.L., C.D.R. Antonielly, P.M.M. Ag-Anne, V.O.S. Jose, W.G.O.F. Jose, R.O.F. Jose, V.O.B.A. Marcus, M.O.F.M. Ana, N.K. Ishaq, I. Amirul, J.U. Shaikh, S.A. Eunus, T.I. Muhammad, T. Swati, K.M. Siddhartha, S.M. Mohammad and A.C.M.C. Ana. 2018. Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review. Phytother. Res. 32:1885-1907. https://doi.org/10.1002/ptr.6134
  18. Ryu, H.S. 2007. The effects of Zingiber officinale Roscoe extracts on mouse IFN-γ and IL-10 production. Korean J. Food & Nutr. 20:259-264.
  19. Seo, Y.H. 2017. Antioxidant and antimicrobial activities of ginger with aging and fermentation. Korean J. Food Preserv. 24:1180-1187. https://doi.org/10.11002/kjfp.2017.24.8.1180
  20. Sheo, H.J. 1999. The antibacterial action of garlic, onion, ginger and red pepper juice. J. Korean Soc. Food Sci. Nutr. 28:94-99.
  21. Son, J.Y. 2010. Antioxidant and antimicrobial activities of methanol extracts from spices. J. Korean Soc. Food Sci. Nutr. 39:648-654. https://doi.org/10.3746/jkfn.2010.39.5.648
  22. Sung, T.H., I.S. Um, O.S. Heo and M.R. Kim. 2003. Quality characteristics of ginger tea. J. Korean Soc. Food Sci. Nutr. 32:47-51. https://doi.org/10.3746/jkfn.2003.32.1.047
  23. Urso, M.L. and P.M. Clarkson. 2003. Oxidative stress, exercise, and antioxidant supplementation. Toxicol. 15:41-54. https://doi.org/10.1016/S0300-483X(03)00151-3
  24. Vistica, D.T., P. Skehan, D. Scudiero, A. Monks, A. Pittman and M.R. Boyd. 1991. Tetrazolium-based assays for cellular viability: A critical examination of selected parameters affecting formazan production. Cancer Res. 51:2515-2520.