대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제42권3호
  • /
  • Pages.107-115
  • /
  • 2021
  • /
  • 1229-0807(pISSN)
  • /
  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지
DOI QR코드

DOI QR Code

경피적 전기 신경 자극의 적용 부위에 따른 자율신경계 활성도 변화 비교 및 평가

Comparison and Evaluation of Autonomic Nervous System (ANS) Activity According to the Stimulus Position of Transcutaneous Electrical Nerve Stimulation (TENS)

  • Park, Seung Won (Department of Biomedical Engineering, Yonsei University) ;
  • Choi, Jun Won (Department of Biomedical Engineering, Yonsei University College of Health Sciences, Yonsei University) ;
  • Jeong, Myeon Gyu (Hyundai Motor Company) ;
  • Lee, Kang In (Hyundai Motor Company) ;
  • Kim, Han Sung (Department of Biomedical Engineering, Yonsei University College of Health Sciences, Yonsei University)
  • 투고 : 2021.05.06
  • 심사 : 2021.06.25
  • 발행 : 2021.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: The aim of this study is to find the location of acupoints that are effective for increasing parasympathetic nervous system(PNS) activity among acupoints used to relieve symptoms such as dizziness and nausea. Materials and Methods: Twenty healthy adult men participated in this experiment. Transcutaneous electrical nerve stimulation(TENS) was applied to P6(Neiguan), ST36(Zusanli) and BL20(Pishu) for 30 minutes. For 5 minutes before and after stimulation, Electrocardiogram(ECG), Electrodermal activity(EDA), Respiration, and Skin temperature(SKT) were measured using biosignalsplux Professional(biosignalsplux; Portugal). Paired t-test was performed for the results before and after stimulation, and a one-way ANOVA test between stimulations was performed for the rate of change before and after stimulation. Results: When each acupoint was stimulated with TENS, it was found that the PNS was generally activated. In addition, when considering the change in biosignals after stimulation, the participants stimulated with P6 showed the most consistent results. Conclusion: As a result of stimulating each acupoint, it was found that stimulating P6 can effectively increase PNS activity. These results indicate that methods of stimulating P6 may be most effective in alleviating symptoms of motion sickness.

키워드

과제정보

본 연구는 (주)현대자동차의 지원을 받아 수행하였음.

참고문헌

  1. Nager AL, et al. Effects of acupuncture on pain and inflammation in pediatric emergency department patients with acute appendicitis: a pilot study. The Journal of Alternative and Complementary Medicine. 2015;21(5):269-272. https://doi.org/10.1089/acm.2015.0024
  2. Sok SR, Erlen JA, Kim KB. Effects of acupuncture therapy on insomnia. Journal of Advanced Nursing. 2003;44(4): 375-384. https://doi.org/10.1046/j.0309-2402.2003.02816.x
  3. Zhang ZJ, et al. The effectiveness and safety of acupuncture therapy in depressive disorders: systematic review and meta-analysis. Journal of affective disorders. 2010;124(1-2):9-21. https://doi.org/10.1016/j.jad.2009.07.005
  4. Galantino ML, et al. Acupuncture as an adjuvant modality with physical therapy for patients with knee osteoarthritis. Medical Acupuncture. 2009;21(3):157-166. https://doi.org/10.1089/acu.2008.0661
  5. Ma T, et al. A study on the clinical effects of physical therapy and acupuncture to treat spontaneous frozen shoulder. The American journal of Chinese medicine. 2006;34(05):759-775. https://doi.org/10.1142/S0192415X06004272
  6. Wu P, et al. Acupuncture in poststroke rehabilitation: a systematic review and meta-analysis of randomized trials. Stroke. 2010;41(4):e171-e179. https://doi.org/10.1161/STROKEAHA.109.573576
  7. Xinnong C. Acupuncture analgesia. Chinese acupuncture and moxibustion. Beijing: Foreign Languages Press. 1987:513-23.
  8. Tan H, et al. Understanding acupoint sensitization: a narrative review on phenomena, potential mechanism, and clinical application. Evidence-Based Complementary and Alternative Medicine. 2019.
  9. Li F, et al. What is the Acupoint? A preliminary review of Acupoints. Pain Medicine. 2015;16(10):1905-1915. https://doi.org/10.1111/pme.12761
  10. Xing JJ, et al. Acupuncture point specificity. International review of neurobiology. 2013;111:49-65. https://doi.org/10.1016/B978-0-12-411545-3.00003-1
  11. Zhou W, Benharash P. Effects and mechanisms of acupuncture based on the principle of meridians. Journal of acupuncture and meridian studies. 2014;7(4):190-193. https://doi.org/10.1016/j.jams.2014.02.007
  12. Lu Y, et al. Anatomic structure of Shaoze (SI 1), Qiangu (SI 2), Houxi (SI 3), Yanggu (SI 5) and Xiaohai (SI 8) regions of Hand-Taiyang Meridian in the rabbit's forelimb. Zhen ci yan jiu= Acupuncture research. 2013;38(6):473-477.
  13. Sun XG, et al. Macroscopical anatomic structure of acupoint Shangyang (LI 1), Erjian (LI 2), Sanjian (LI 3), Hegu (LI 4), and Quchi (LI 11) regions in the forelimb in rabbits. Zhen ci yan jiu= Acupuncture research. 2012;37(1):31-37.
  14. Lou XF, Jiang SH. Anatomical characters and classification of acupoint. Zhongguo zhen jiu=Chinese acupuncture & moxibustion. 2012;32(4):319-323.
  15. Napadow V, et al. Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Human brain mapping. 2005;24(3):193-205. https://doi.org/10.1002/hbm.20081
  16. Fydanaki O, et al. Electroacupuncture could reduce motion sickness susceptibility in healthy male adults: a double-blinded study. Medical acupuncture. 2017;29(6):377-382. https://doi.org/10.1089/acu.2017.1246
  17. Shiao SYPK, Dune LS. Metaanalyses of acustimulations: effects on nausea and vomiting in postoperative adult patients. Explore. 2006;2(3):202-215. https://doi.org/10.1016/j.explore.2006.02.005
  18. Tsui P, Leung MC. Comparison of the effectiveness between manual acupuncture and electro-acupuncture on patients with tennis elbow. Acupuncture & electro-therapeutics research. 2002;27(2):107-117. https://doi.org/10.3727/036012902816026040
  19. Lv JQ, Feng RZ, Li N. P6 acupoint stimulation for prevention of postoperative nausea and vomiting in patients under-going craniotomy: study protocol for a randomized controlled trial. Trials. 2013;14(1):1-7. https://doi.org/10.1186/1745-6215-14-1
  20. Cheung, MC, Chan AS, Yip J. Microcurrent stimulation at shenmen acupoint facilitates EEG associated with sleepiness and positive mood: a randomized controlled electrophysiological study. Evidence-Based Complementary and Alternative Medicine. 2015;2015.
  21. Kim SB, et al. Comparison of 2 methods of non-invasive treatment between transcutaneous electrical stimulation and pulsed electromagnetic field stimulation as replacement of invasive manual acupuncture. Acupuncture & electro-therapeutics research. 2013;37(4):247-261. https://doi.org/10.3727/036012912X13831831256294
  22. Wang B, et al. Effect of the intensity of transcutaneous acupoint electrical stimulation on the postoperative analgesic requirement. Anesthesia & Analgesia. 1997;85(2):406-413. https://doi.org/10.1213/00000539-199708000-00029
  23. White A, et al. Survey of adverse events following acupuncture (SAFA): a prospective study of 32,000 consultations. Acupuncture in Medicine. 2001;19(2):84-92. https://doi.org/10.1136/aim.19.2.84
  24. Sanderson JE, et al. The effect of transcutaneous electrical nerve stimulation (TENS) on autonomic cardiovascular reflexes. Clinical Autonomic Research. 1995;5(2):81-84. https://doi.org/10.1007/BF01827467
  25. Van Dijk, KR, et al. Effects of transcutaneous electrical nerve stimulation (TENS) on non-pain related cognitive and behavioural functioning. Reviews in the Neurosciences. 2002;13(3):257-270.
  26. Agelink M, et al. Does acupuncture influence the cardiac autonomic nervous system in patients with minor depression or anxiety disorders? Fortschritte der Neurologie-psychiatrie. 2003;71(3):141-149. https://doi.org/10.1055/s-2003-37756
  27. Chu H, et al. Effects of transcutaneous electrical nerve stimulation on motion sickness induced by rotary chair: a crossover study. The Journal of Alternative and Complementary Medicine. 2012;18(5):494-500. https://doi.org/10.1089/acm.2011.0366
  28. Sakatani K, et al., Effects of acupuncture on autonomic nervous function and prefrontal cortex activity, in Oxygen Transport to Tissue XXXI. Springer. 2010. pp. 455-460.
  29. Wibirama S, Hamamoto K. Investigation of visually induced motion sickness in dynamic 3D contents based on subjective judgment, heart rate variability, and depth gaze behavior. 2014 36th annual international conference of the IEEE engineering in medicine and biology society. 2014;4803-4806.
  30. Yokota Y, et al. Motion sickness susceptibility associated with visually induced postural instability and cardiac autonomic responses in healthy subjects. Acta oto-laryngologica. 2005;125(3):280-285. https://doi.org/10.1080/00016480510003192
  31. Cowings PS, Naifeh KH, Toscano WB. The stability of individual patterns of autonomic responses to motion sickness stimulation. Aviation, space, and environmental medicine. 1990;61(5):399-405.
  32. Cowings PS, et al. General autonomic components of motion sickness. Psychophysiology. 1986;23(5):542-551. https://doi.org/10.1111/j.1469-8986.1986.tb00671.x
  33. Stern RM, et al. Acupressure Relieves the Symptons of Motion Sickness and Reduces Abnormal Gatric Activity. Alternative therapies in health and medicine. 2001;7(4):91.
  34. Takahashi T. Acupuncture for functional gastrointestinal disorders. Journal of gastroenterology. 2006;41(5):408-417. https://doi.org/10.1007/s00535-006-1773-6
  35. Kotani N, et al. Preoperative intradermal acupuncture reduces postoperative pain, nausea and vomiting, analgesic requirement, and sympathoadrenal responses. The Journal of the American Society of Anesthesiologists. 2001;95(2):349-356.
  36. Charlton E. Ethical guidelines for pain research in humans. Committee on Ethical Issues of the International Association for the Study of Pain. Pain. 1995;63(3):277-278. https://doi.org/10.1016/0304-3959(95)90040-3
  37. Stein C, et al. Transcutaneous electrical nerve stimulation at different frequencies on heart rate variability in healthy subjects. Autonomic Neuroscience. 2011;165(2):205-208. https://doi.org/10.1016/j.autneu.2011.07.003
  38. Lim S. WHO standard acupuncture point locations. EvidenceBased Complementary and Alternative Medicine. 2010;7(2):167-168.
  39. PLUX Wireless Biosignals S.A.: 'Biosignalsplux user manual'. Available from: https://biosignalsplux.com/downloads/docs/manuals/biosignalsplux_User_Manual.pdf.
  40. Electrocardiography (ECG) Sensor User Manual. Available from: https://biosignalsplux.com/downloads/docs/manuals/Electrocardiography_(ECG)_User_Manual.pdf.
  41. Camm AJ, et al. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation. 1996;93(5):1043-1065. https://doi.org/10.1161/01.CIR.93.5.1043
  42. Pan J, Tompkins WJ. A real-time QRS detection algorithm. IEEE transactions on biomedical engineering. 1985;(3):230-236.
  43. Heinisch JS, Hubener I, David K. The Impact of Physical Activities on the Physiological Response to Emotions. 2018 IEEE International Conference on Pervasive Computing and Communications Workshops (PerCom Workshops). 2018; 824-829.
  44. Posada-Quintero HF, et al. Power spectral density analysis of electrodermal activity for sympathetic function assessment. Annals of biomedical engineering. 2016;44(10):3124-3135. https://doi.org/10.1007/s10439-016-1606-6
  45. Critchley HD. Electrodermal responses: what happens in the brain. The Neuroscientist. 2002;8(2):132-142. https://doi.org/10.1177/107385840200800209
  46. Freeman R, Chapleau MW. Testing the autonomic nervous system. Handbook of clinical neurology. 2013;115:115-136. https://doi.org/10.1016/B978-0-444-52902-2.00007-2
  47. Blazquez A, et al. Wrist skin temperature, motor activity, and body position as determinants of the circadian pattern of blood pressure. Chronobiology international. 2012;29(6):747-756. https://doi.org/10.3109/07420528.2012.679328
  48. Kitney R, Rompelman O, The study of heart-rate variability. 1980: Oxford University Press, USA.
  49. Mackersie CL, Calderon-Moultrie N. Autonomic nervous system reactivity during speech repetition tasks: Heart rate variability and skin conductance. Ear and Hearing. 2016;37:118S-125S. https://doi.org/10.1097/AUD.0000000000000305
  50. Muth ER. Motion and space sickness: intestinal and autonomic correlates. Autonomic Neuroscience. 2006;129(1-2):58-66. https://doi.org/10.1016/j.autneu.2006.07.020
  51. Benedek M, Kaernbach C. A continuous measure of phasic electrodermal activity. Journal of neuroscience methods. 2010;190(1):80-91. https://doi.org/10.1016/j.jneumeth.2010.04.028
  52. Ellaway P, et al. Sweat production and the sympathetic skin response: Improving the clinical assessment of autonomic function. Autonomic Neuroscience. 2010;155(1-2):109-114. https://doi.org/10.1016/j.autneu.2010.01.008
  53. Healey JA, Picard RW. Detecting stress during real-world driving tasks using physiological sensors. IEEE Transactions on intelligent transportation systems. 2005;6(2):156-166. https://doi.org/10.1109/TITS.2005.848368
  54. Illigens BM, Gibbons CH. Sweat testing to evaluate autonomic function. Clinical Autonomic Research. 2009;19(2):79. https://doi.org/10.1007/s10286-008-0506-8
  55. Setz C, et al. Discriminating stress from cognitive load using a wearable EDA device. IEEE Transactions on information technology in biomedicine. 2009;14(2):410-417. https://doi.org/10.1109/TITB.2009.2036164
  56. Lin HP, et al. Effects of stress, depression, and their interaction on heart rate, skin conductance, finger temperature, and respiratory rate: sympathetic-parasympathetic hypothesis of stress and depression. Journal of clinical psychology. 2011;67(10):1080-1091. https://doi.org/10.1002/jclp.20833
  57. Nobel G, et al. Motion sickness increases the risk of accidental hypothermia. European journal of applied physiology. 2006;98(1):48-55. https://doi.org/10.1007/s00421-006-0217-6
  58. Sallam HS, Song J, Chen JZ. Electroacupuncture via chronically implanted electrodes: potential treatment for chemotherapy-induced delayed emesis. Neuromodulation: Technology at the Neural Interface. 2015;18(6):494-498. https://doi.org/10.1111/ner.12303