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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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CD1d deficiency limits tolerogenic properties of peritoneal macrophages

  • Basri, Fathihah (Department of Life Sciences, Korea University) ;
  • Jung, Sundo (Department of Biomedical Laboratory Science, Shinhan University) ;
  • Park, Se Hoon (Department of Life Sciences, Korea University) ;
  • Park, Se-Ho (Department of Life Sciences, Korea University)
  • Received : 2020.08.31
  • Accepted : 2020.12.10
  • Published : 2021.04.30
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Abstract

Invariant natural killer T (iNKT) cells are involved in various autoimmune diseases. Although iNKT cells are arthritogenic, transforming growth factor beta (TGFβ)-treated tolerogenic peritoneal macrophages (Tol-pMφ) from wild-type (WT) mice are more tolerogenic than those from CD1d knock-out iNKT cell-deficient mice in a collagen-induced arthritis (CIA) model. The underlying mechanism by which pMφ can act as tolerogenic antigen presenting cells (APCs) is currently unclear. To determine cellular mechanisms underlying CD1d-dependent tolerogenicity of pMφ, in vitro and in vivo characteristics of pMφ were investigated. Unlike dendritic cells or splenic Mφ, pMφ from CD1d+/- mice showed lower expression levels of costimulatory molecule CD86 and produced lower amounts of inflammatory cytokines upon lipopolysaccharide (LPS) stimulation compared to pMφ from CD1d-deficient mice. In a CIA model of CD1d-deficient mice, adoptively transferred pMφ from WT mice reduced the severity of arthritis. However, pMφ from CD1d-deficient mice were unable to reduce the severity of arthritis. Hence, the tolerogenicity of pMφ is a cell-intrinsic property that is probably conferred by iNKT cells during pMφ development rather than by interactions of pMφ with iNKT cells during antigen presentation to cognate T cells.

Keywords

Acknowledgement

This work was supported by a grant (NRF-2018R1A2A2A05023297) of the Basic Science Research Program of the National Research Foundation of Korea and a grant (K2010761) from Korea University. We thank crews of Geyrim Experimental Animal Resource Center for their assistance in animal handling and maintenance.

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