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http://dx.doi.org/10.5483/BMBRep.2021.54.4.183

CD1d deficiency limits tolerogenic properties of peritoneal macrophages  

Basri, Fathihah (Department of Life Sciences, Korea University)
Jung, Sundo (Department of Biomedical Laboratory Science, Shinhan University)
Park, Se Hoon (Department of Life Sciences, Korea University)
Park, Se-Ho (Department of Life Sciences, Korea University)
Publication Information
BMB Reports / v.54, no.4, 2021 , pp. 209-214 More about this Journal
Abstract
Invariant natural killer T (iNKT) cells are involved in various autoimmune diseases. Although iNKT cells are arthritogenic, transforming growth factor beta (TGFβ)-treated tolerogenic peritoneal macrophages (Tol-pMφ) from wild-type (WT) mice are more tolerogenic than those from CD1d knock-out iNKT cell-deficient mice in a collagen-induced arthritis (CIA) model. The underlying mechanism by which pMφ can act as tolerogenic antigen presenting cells (APCs) is currently unclear. To determine cellular mechanisms underlying CD1d-dependent tolerogenicity of pMφ, in vitro and in vivo characteristics of pMφ were investigated. Unlike dendritic cells or splenic Mφ, pMφ from CD1d+/- mice showed lower expression levels of costimulatory molecule CD86 and produced lower amounts of inflammatory cytokines upon lipopolysaccharide (LPS) stimulation compared to pMφ from CD1d-deficient mice. In a CIA model of CD1d-deficient mice, adoptively transferred pMφ from WT mice reduced the severity of arthritis. However, pMφ from CD1d-deficient mice were unable to reduce the severity of arthritis. Hence, the tolerogenicity of pMφ is a cell-intrinsic property that is probably conferred by iNKT cells during pMφ development rather than by interactions of pMφ with iNKT cells during antigen presentation to cognate T cells.
Keywords
CD1d; CIA; NKT cells; Peritoneal macrophage; Rheumatoid arthritis;
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1 Hughes FM Jr, Pringle CM and Gorospe WC (1991) Production of progestin-stimulatory factor(s) by enriched populations of rat T and B lymphocytes. Biol Reprod 44, 922-926   DOI
2 Weiss A, Irving BA, Tan LK and Koretzky GA (1991) Signal transduction by the T cell antigen receptor. Semin Immunol 3, 313-324
3 Bendelac A, Rivera MN, Park SH and Roark JH (1997) Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu Rev Immunol 15, 535-562   DOI
4 Bleicher PA, Balk SP, Hagen SJ, Blumberg RS, Flotte TJ and Terhorst C (1990) Expression of murine CD1 on gastrointestinal epithelium. Science 250, 679-682   DOI
5 Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ and Van Kaer L (2004) Opinion - NKT cells: what's in a name? Nat Rev Immunol 4, 231-237   DOI
6 Lang GA, Devera TS and Lang ML (2008) Requirement for CD1d expression by B cells to stimulate NKT cell-enhanced antibody production. Blood 111, 2158-2162   DOI
7 Lang GA, Exley MA and Lang ML (2006) The CD1d-binding glycolipid alpha-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1ddependent manner. Immunology 119, 116-125   DOI
8 Brand DD, Latham KA and Rosloniec EF (2007) Collagen-induced arthritis. Nat Protocols 2, 1269-1275   DOI
9 Jung S, Park YK, Shin JH et al (2010) The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis. Exp Mol Med 42, 547-554   DOI
10 Nakamura T, Kamogawa Y, Botomly K and Flavell RA (1997) Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells. J Immunol 158, 1085-1094
11 Kojo S, Seino K, Harada M et al (2005) Induction of regulatory properties in dendritic cells by Valpha14 NKT cells. J Immunol 175, 3648-3655   DOI
12 Chiba A, Kaieda S, Oki S, Yamamura T and Miyake S (2005) The involvement of V(alpha)14 natural killer T cells in the pathogenesis of arthritis in murine models. Arthritis Rheum 52, 1941-1948   DOI
13 Coppieters K, Van Beneden K, Jacques P et al (2007) A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner. J Immunol 179, 2300-2309   DOI
14 Ko HJ, Lee JM, Kim YJ, Kim YS, Lee KA and Kang CY (2009) Immunosuppressive myeloid-derived suppressor cells can be converted into immunogenic APCs with the help of activated NKT cells: an alternative cell-based antitumor vaccine. J Immunol 182, 1818-1828   DOI
15 Teige A, Bockermann R, Hasan M, Olofsson KE, Liu Y and Issazadeh-Navikas S (2010) CD1d-dependent NKT cells play a protective role in acute and chronic arthritis models by ameliorating antigen-specific Th1 responses. J Immunol 185, 345-356   DOI
16 Teige A, Teige I, Lavasani S et al (2004) CD1-dependent regulation of chronic central nervous system inflammation in experimental autoimmune encephalomyelitis. J Immunol 172, 186-194   DOI
17 Brandes M, Willimann K and Moser B (2005) Professional antigen-presentation function by human gamma delta T cells. Science 309, 264-268   DOI
18 Wilbanks GA, Mammolenti M and Streilein JW (1991) Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID. J Immunol 146, 3018-3024
19 Hegde S, Fox L, Wang XH and Gumperz JE (2010) Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells. Immunology 130, 471-483   DOI
20 Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E and Burmester GR (2000) Macrophages in rheumatoid arthritis. Arthritis Res 2, 189-202   DOI
21 D'Orazio TJ and Niederkorn JY (1998) Splenic B cells are required for tolerogenic antigen presentation in the induction of anterior chamber-associated immune deviation (ACAID). Immunology 95, 47-55   DOI
22 Palmer JL, Tulley JM, Kovacs EJ, Gamelli RL, Taniguchi M and Faunce DE (2006) Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and CD1d-restricted NKT cells. J Immunol 177, 92-99   DOI
23 Xu Y and Kapp JA (2001) Gammadelta T cells are critical for the induction of anterior chamber-associated immune deviation. Immunology 104, 142-148   DOI
24 Sonoda KH, Exley M, Snapper S, Balk SP and Stein-Streileinl J (1999) CDI reactive NKT cells are required for development of systemic tolerance through an immune privileged site. J Exp Med 190, 1215-1226   DOI
25 Kojo S, Tsutsumi A, Goto D and Sumida T (2003) Low expression levels of soluble CD1d gene in patients with rheumatoid arthritis. J Rheumatol 30, 2524-2528