Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
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Dexamethasone reduces infectious bursal disease mortality in chickens

  • Shin, Seung Yub (Department of Veterinary Pharmacology and Research Center and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University) ;
  • Han, Tae Hee (Department of Veterinary Pharmacology and Research Center and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University) ;
  • Kwon, Hyuk Joon (Farm Animal Clinical Training, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Sun Joong (Department of Avian Diseases, College of Veterinary Medicine, Seoul National University) ;
  • Ryu, Pan Dong (Department of Veterinary Pharmacology and Research Center and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University)
  • Received : 2020.09.28
  • Accepted : 2021.02.21
  • Published : 2021.05.31
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Abstract

Very virulent infectious bursal disease virus (vvIBDV) causes high mortality in chickens but measures to reduce the mortality have not been explored. Chickens (8-9 weeks) were treated with 3 agents before and during vvIBDV inoculation. Dexamethasone treatment reduced the mortality of infected chickens (40.7% vs. 3.7%; p < 0.001), but treatment with aspirin or vitamin E plus selenium did not affect the mortality. The bursa of Fabricius appeared to have shrunk in both dead and surviving chickens (p < 0.01). The results indicate that dexamethasone can reduce mortality in vvIBDV-infected chickens and may provide therapeutic clues for saving individual birds infected by the virus.

Keywords

Acknowledgement

This work was supported by the Technology Development Program for Agriculture and Forestry, Ministry for Food, Agriculture, Forestry and Fisheries, and the Korea Research Foundation Grant to SJK (KRF-2006-005-J02903) and a grant of the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology funded by the Korean Government to PDR (2018R1D1A1B07043448).

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