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http://dx.doi.org/10.4142/jvs.2021.22.e33

Dexamethasone reduces infectious bursal disease mortality in chickens  

Shin, Seung Yub (Department of Veterinary Pharmacology and Research Center and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University)
Han, Tae Hee (Department of Veterinary Pharmacology and Research Center and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University)
Kwon, Hyuk Joon (Farm Animal Clinical Training, College of Veterinary Medicine, Seoul National University)
Kim, Sun Joong (Department of Avian Diseases, College of Veterinary Medicine, Seoul National University)
Ryu, Pan Dong (Department of Veterinary Pharmacology and Research Center and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University)
Publication Information
Journal of Veterinary Science / v.22, no.3, 2021 , pp. 33.1-33.6 More about this Journal
Abstract
Very virulent infectious bursal disease virus (vvIBDV) causes high mortality in chickens but measures to reduce the mortality have not been explored. Chickens (8-9 weeks) were treated with 3 agents before and during vvIBDV inoculation. Dexamethasone treatment reduced the mortality of infected chickens (40.7% vs. 3.7%; p < 0.001), but treatment with aspirin or vitamin E plus selenium did not affect the mortality. The bursa of Fabricius appeared to have shrunk in both dead and surviving chickens (p < 0.01). The results indicate that dexamethasone can reduce mortality in vvIBDV-infected chickens and may provide therapeutic clues for saving individual birds infected by the virus.
Keywords
Very virulent infectious bursal disease virus; nitric oxide; bursa of Fabricius; bursa-to-body-weight ratio; aspirin; vitamin E; selenium;
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