Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
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Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls

  • Mizuguchi, Hitoshi (DKK-Toa Yamagata Co.) ;
  • Kizaki, Keiichiro (Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University) ;
  • Kimura, Atsushi (Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University) ;
  • Kushibiki, Shiro (Institute of Livestock and Grassland Science, NARO) ;
  • Ikuta, Kentaro (Awaji Agricultural Technology Center) ;
  • Kim, Yo-Han (Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University) ;
  • Sato, Shigeru (Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University)
  • Received : 2021.01.26
  • Accepted : 2021.03.19
  • Published : 2021.05.31
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Abstract

Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was administered once daily for 14 days. Significantly lower ruminal LPS and higher 1-h mean ruminal pH were identified in the 4 g group. However, blood metabolites, acute-phase proteins, cytokines, and hepatic transcriptomes were not different between the two groups. Therefore, anti-LPS antibody administration mitigated ruminal LPS release and pH depression without accompanying responses in acute-phase inflammation or hepatic transcriptomic expression.

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References

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