한방비만학회지 (Journal of Korean Medicine for Obesity Research)

  • 제21권2호
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  • Pages.59-68
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  • 2021
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  • 1976-9334(pISSN)
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  • 2288-1522(eISSN)
한방비만학회 (The Society of Korean Medicine for obesity Research)
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고지방식이 유도 비만 마우스에서 황련, 단삼, 육계 복합추출물의 비만 개선 및 당뇨 예방 효과

Anti-Obesity and Anti-Diabetic Effects of a Polyherbal Extract Consisting of Coptidis Rhizoma, Salviae Miltiorrhizae Radix, and Cinnamomi Cortex in High Fat Diet-Induced Obesity Mice

  • 정수민 (동국대학교 한의과대학 본초학교실) ;
  • 권세은 (동국대학교 한의과대학 본초학교실) ;
  • 강석용 (동국대학교 한방신약개발센터) ;
  • 김수진 (동국대학교 의과대학 경주병원 마취통증의학교실) ;
  • 정효원 (동국대학교 한의과대학 본초학교실) ;
  • 박용기 (동국대학교 한의과대학 본초학교실)
  • Jung, Su Min (Department of Herbology, College of Korean Medicine, Dongguk University) ;
  • Kwon, Se Eun (Department of Herbology, College of Korean Medicine, Dongguk University) ;
  • Kang, Seok Yong (Korean Medicine R&D Institute, Dongguk University) ;
  • Kim, Su Jin (Department of Anesthesiology and Pain Medicine, Dongguk University Gyeongju Hospital, College of Medicine, Dongguk University) ;
  • Jung, Hyo Won (Department of Herbology, College of Korean Medicine, Dongguk University) ;
  • Park, Yong-Ki (Department of Herbology, College of Korean Medicine, Dongguk University)
  • 투고 : 2021.10.22
  • 심사 : 2021.11.20
  • 발행 : 2021.12.30
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초록

Objectives: We investigated the effects of Clean-DM4 (C-DM4), a polyherbal extract consisting of Coptidis Rhizoma, Salviae Miltiorrhiza Radix, and Cinnamomi Cortex on high fat diet (HFD)-induced obesity and diabetes in mice. Methods: The C57BL/6 mice (6 weeks) were fed a HFD for 8 weeks and then administrated with C-DM4 extract at 500 mg/kg (p.o.) once daily for 4 weeks. The changes of body weights, calorie intakes, and fasting blood glucose (FBG) levels were measured in mice. The serum levels of glucose, insulin, total cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured in mice by enzyme-based assay. It was also observed the histological changes of pancreas, liver, and fat tissues with hematoxylin and eosin (H&E) staining. Results: The increase of calorie intakes and FBG levels in HFD-induced obesity mice was significantly decreased by oral administration of C-DM4 extract. C-DM4 extract administration was significantly reduced the increased levels of glucose, insulin, total cholesterol, AST, and ALT in obesity mice. In addition, C-DM4 extract inhibited lipid droplet accumulation in liver tissues of obesity mice, hyperplasia of pancreatic islets, and enlargement of adipocytes in adipose tissues. Conclusions: Our study indicates that C-DM4 extract could help improve obesity and to prevent diabetes progression.

키워드

과제정보

이 논문은 2020년도 한국보건산업진흥원 '한의약혁신기술개발사업'의 연구비 지원으로 수행되었음(HF20C0121).

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