Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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Effects of White Pan Bread Added with Kamut (Triticum turgidum spp.) on High Fat Diet-Induced Obese C57BL/6 Mice

Kamut (Triticum turgidum spp.) 식빵 급여가 고지방식이 유도 비만 C57BL/6 마우스에 미치는 효과

  • Jung, Hyun Gi (Department of Food Science, Gyeongsang National University) ;
  • Baek, Ji Yun (Department of Food Science, Gyeongsang National University) ;
  • Choi, Ye Jung (College of Korean Medicine, Gachon University) ;
  • Kang, Ki Sung (College of Korean Medicine, Gachon University) ;
  • Kim, Hyun Young (Department of Food Science, Gyeongsang National University) ;
  • Kim, Ji Hyun (Department of Food Science, Gyeongsang National University) ;
  • Choi, Jine Shang (Department of Food Science, Gyeongsang National University)
  • 정현기 (경상국립대학교 식품과학부) ;
  • 백지윤 (경상국립대학교 식품과학부) ;
  • 최예정 (가천대학교 한의과대학) ;
  • 강기성 (가천대학교 한의과대학) ;
  • 김현영 (경상국립대학교 식품과학부) ;
  • 김지현 (경상국립대학교 식품과학부) ;
  • 최진상 (경상국립대학교 식품과학부)
  • Received : 2021.10.07
  • Accepted : 2021.11.12
  • Published : 2021.12.30
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Abstract

Objectives: The purpose of this study was to investigate the effect of white pan bread added with Kamut (Triticum turgidum spp.) on high fat diet (HFD)-induced obese C57BL/6 mice. Methods: The white pan bread or white pan bread with Kamut (BK) were administered for 8 weeks in HFD-induced obese C57BL/6 mice. To evaluate the effect and its mechanisms of BK on obese mice, we measured body weight change, serum lipid profiles, histopathological analysis, and protein expression of CCAAT/enhancer binding protein-α (C/EBPα) in the liver. Results: Administration of BK significantly decreased body weight in HFD-induced obese mice. In addition, BK-administered group significantly reduced serum total cholesterol, glucose, and high-density lipoprotein cholesterol levels compared with the HFD-induced control group. The HFD-induced mice had damaged liver tissue and increased the size of adipose tissue, but BK-administered group attenuated liver damage and decreased the size of adipocyte. Furthermore, administration of BK significantly down-regulated C/EBPα in the liver compared with HFD-fed mice. In particular, BK-administered group has higher inhibited body weight, serum lipid profiles, and C/EBPα expressions than white pan bread-administered group. Conclusions: This study demonstrated that administration of BK attenuated HFD-induced obesity by regulation of C/EBPα than consumption of white pan bread. Therefore, BK could be developed as a bread for prevention of obesity.

Keywords

Acknowledgement

본 연구는 2020~2021년도 경상국립대학교 대학회계 연구비 지원에 의하여 연구되었음.

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