Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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A clear cell hepatocellular carcinoma in an obese dog with hyperlipidemia: a case report

  • Jung, Jae-Ha (Department of Veterinary Clinical Pathology, Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Lee, MaRo (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Yang, Yeseul (Department of Veterinary Clinical Pathology, Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Seo, Dansong (Department of Veterinary Clinical Pathology, Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Hwang, Sung-Hyun (Department of Veterinary Clinical Pathology, Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Wan Hee (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Yongbaek (Department of Veterinary Clinical Pathology, Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University)
  • Received : 2021.08.04
  • Accepted : 2021.10.02
  • Published : 2021.12.31
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Abstract

An 11-year-old obese dog was referred for a liver mass. Cytologic examination revealed vacuolated hepatocytes with mild pleomorphism. A partial liver lobectomy was performed. On histopathologic examination, the mass was diagnosed as hepatocellular carcinoma composed of hepatocytes with clear vacuoles. These findings were consistent with clear cell hepatocellular carcinoma (CCHCC). The CCHCC is a rare subtype of hepatocellular carcinoma in dogs, and clinical features are poorly defined. This is the first report on the cytological, histological and clinical aspects of CCHCC, suggesting that obesity and hyperlipidemia are potential risk factors for CCHCC in dogs.

Keywords

Acknowledgement

This study was supported by the Research Institute for Veterinary Science, Seoul National University.

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