Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Potential of Baeyer-Villiger monooxygenases as an enzyme for polyethylene decomposition

폴리에틸렌 분해를 위한 효소로써 Baeyer-Villiger monooxygenases의 잠재력

  • Yoon, Ye Rin (Division of Applied Life Science (BK21), Department of Applied Life Chemistry, Institute of Agriculture & Life Science (IALS), Gyeongsang National University (GNU)) ;
  • Jang, Yu-Sin (Division of Applied Life Science (BK21), Department of Applied Life Chemistry, Institute of Agriculture & Life Science (IALS), Gyeongsang National University (GNU))
  • Received : 2021.11.03
  • Accepted : 2021.11.16
  • Published : 2021.12.31
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Abstract

Polyethylene is widely used as an agricultural film, but eco-friendly technology is lacking for its decomposition. Thus, recently, much attention has been paid to develop a technology for biological polyethylene decomposition. It has been expected that several oxidation steps will be required in the biological degradation of polyethylene. First, secondary alcohol is formed on the polyethylene chain, and then the alcohol is oxidized to a carbonyl group. In the subsequent process, the carbonyl group is converted to an ester by Baeyer-Villiger monooxygenase (BVMO), and this ester bond is expected to be cleaved by lipase and esterase in the final step. In this work, we reviewed BVMO as one of the promising enzymes for polyethylene decomposition, in terms of its reaction mechanism, classification, and engineering. In addition, we also give a brief perspective on polyethylene decomposition using BVMO.

폴리에틸렌은 농업용 필름으로 널리 사용되고 있지만, 이를 친환경적으로 분해하기 위한 기술은 부족한 상황이다. 이에 최근 폴리에틸렌 분해를 위한 친환경 기술 개발에 대한 관심이 높아지고 있다. 폴레에틸렌의 생물학적 분해에는 몇가지 산화 단계가 필요할 것이라고 예상된다. 먼저, 폴리에틸렌 사슬에 2차 알코올이 형성되고, 알코올은 카르보닐기로 산화된다. 이후 과정에서 카르보닐기는 Baeyer-Villiger monooxygenase (BVMO)에 의해 에스터로 전환되고, 이 에스터는 마지막 단계에서 lipase와 esterase에 의해 절단될 것으로 예상된다. 본 연구에서는 폴리에틸렌 분해 과정에 관여하는 중요한 효소 중 하나인 BVMO의 반응 메커니즘, 분류, 효소공학 측면에서 리뷰하였다. 또한 BVMO를 사용한 폴리에틸렌 분해 분야의 향후 연구전망도 간략히 덧붙였다.

Keywords

Acknowledgement

This study was supported by Rural Development Administration, Republic of Korea through the "Cooperative Research Program for Agricultural Science & Technology Development (Project No. PJ01492601)"

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