Effects of Atractylodes lancea on Plasma Glucose and Lipid Profile in Streptozotocin Induced Diabetic Rats

창출(Atractylodes lancea) 추출물의 투여가 당뇨 유발 흰쥐의 혈당과 지질수준에 미치는 영향

  • Han, Hye Kyoung (Dept. of Food and Nutrition, College of Natural Science, Duksung Women's University) ;
  • Choi, Eun Young (Dept. of Food and Nutrition, KyungBuk College)
  • 한혜경 (덕성여자대학교 식품영양학과) ;
  • 최은영 (경북전문대학교 식품영양과)
  • Received : 2020.09.01
  • Accepted : 2020.10.07
  • Published : 2020.10.31


The purpose of this study was to examine the effects of Atractylodes lancea (A.l.) in a dose-dependent manner on lipid levels and plasma glucose in diabetic rats induced with streptozotocin (STZ). The Sprague-Dawley rats were randomly classified into five groups: normal, STZ-control and three experimental groups [A.l.-1, diabetic treated with ethanolic extract of A.l. (1 g/kg b.w.), A.l.-2, diabetic administered with ethanolic extract of A.l. (2 g/kg b.w.), and A.l.-3, diabetic administered with ethanolic extract of A.l. (3 g/kg b.w.)]. The normal and STZ-control group were fed an AIN-93 diet and the three experimental groups were administered with A.l. extract at doses of 1, 2, and 3 g/kg b.w./day, respectively, for 14 days. The plasma glucose levels in all the experimental groups were significantly lower than the STZ-control group after 14 days of treatment. The total cholesterol of the A.l.-3 and triglyceride levels, atherogenic index (AI) of all three experimental groups were significantly lower than the STZ-control group. The ALT and AST activities at A.l.-2, A.l.-3 were significantly lower than the STZ-control group. This result that demonstrate the administration of Atractylodes lancea can reduce hyperglycemia and hyperlipidemia risk in diabetic rats.



  1. Barbera A, Rodriguez-Gil JE, Guinovart JJ. 1994. Insulin-like actions of tungstate in diabetic rats. Normalization of hepatic glucose metabolism. J Biol Chem 269:20047-20053
  2. Brownlee M, Vlassara H, Cerami A. 1984. Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med 101:527-537
  3. Bursch W, Schulte-Hermann R. 1986. Cytoprotective effect of the prostacyclin derivative iloprost against liver cell death induced by the hepatotoxins carbon tetrachloride and bromobenzene. Klin Wochenschr 64:47-50
  4. Choi KS. 2013. Effects of coated liposome from Discorea rhizoma extract (DRE)-on hypoglycemic, serum insulin, and lipid levels in streptozotocin-induced. Korean J Food Nutr 26:310-317
  5. Dai S, Thompson KH, McNeill JH. 1994. One-year treatment of streptozotocin-induced diabetic rats with vanadyl sulphate. Pharmacol Toxicol 74:101-109
  6. Finley PR, Schifman RB, Williams RJ, Lichti DA. 1978. Cholesterol in high-density lipoprotein: Use of $Mg^{2+}$/dextran sulfate in its measurement. Clin Chem 24:931-933
  7. Giegel JL, Ham AB, Clema W. 1975. Manual and semi-automated procedures for measurements of triglycerides in serum. Clin Chem 21:1575-1581
  8. Han HK, Yoon SJ, Kim GH. 2009. Effects of compositae plants on plasma glucose and lipid level in streptozotocin induced diabetic rats. J Korean Soc Food Sci Nutr 38:674-682
  9. Huang HL, Chen CC, Yeh CY, Huang RL. 2005. Reactive oxygen species mediation of Baizhu-induced apoptosis in human leukemia cells. J Ethnopharmacol 97:21-29
  10. Kahn CR. 1985. The molecular mechanism of insulin action. Ann Rev Med 36:449-451
  11. Kanai I, Kanai M. 1983. Compendium of the Clinical Inspection. 29th ed. p.467. Komoonsa
  12. Kim SH, Kang JS, Lee SJ, Chung YJ. 2008. Antidiabetic effect of Korean red ginseng by puffing process in streptozotocininduced diabetic rats. J Korean Soc Food Sci Nutr 37:701-707
  13. Kimura Y, Okuda H, Okuda T, Hatano T, Agata I, Arichi S. 1985. Studies on the activities of tannins and related compounds from medicinal plants and drugs. VII. Effects of extracts of leaves of Artemisia species and caffeic acid chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil. Chem Pharm Bull 33:2028-2034
  14. Lee JW. 2017. Anti-diabetic effect of dried-silkworm Dongchunghacho in streptozotocin-induced diabetic rats. Korean J Food Nutr 30:665-672
  15. Lee NY. 2013. Antioxidant effect and tyrosinase inhibition activity of seaweeds ethanol extracts. J Korean Soc Food Sci Nutr 42:1893-1898
  16. Marles RJ, Farnsworth NR. 1995. Antidiabetic plants and their active constituents. Phytomedicine 2:137-189
  17. O'Brien RM, Granner DK. 1996. Regulation of gene expression by insulin. Physiol Rev 76:1109-1161
  18. Park JH. 2004. Medicinal Plants of Korea. p.1338. Shinilbooks
  19. Raabo E, Terkildsen TC. 1960. On the enzymatic determination of blood glucose. Scandinav J Clin Lab Invest 12:402-407
  20. Reaven GM. 1988. Role of insulin resistance in human disease. Diabetes 37:1597-1607
  21. Reeves PG. 1997. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr 127:838S-841S
  22. Rhee SJ, Shin JY, Cha BG. 1998. Effect of green tea catechin on the microsomal mixed function oxidase system of kidney and brain in streptozotocin-induced diabetic rats. J Korean Soc Food Nutr 27:319-325
  23. Rho HM, Choi M, Koh JB. 1998. Effects of serum raw soy flour (yellow and black) on protein concentrations and enzyme activity. J Korean Soc Food Sci Nutr 27:724-730
  24. Richmond W. 1973. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to enzymatic assay of total cholesterol in serum. Clin Chem 19:1350-1356
  25. Seo KH, Choi JS, Na JO, Uh ST, Kim YH, Park CS. 2006. Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 after administration of endotoxin in diabetic rats. Tuberc Respir Dis 61:256-264
  26. Steer KA, Sochor M, McLean P. 1985. Renal hypertrophy in experimental diabetes changes in pentose phosphate pathway activity. Diabetes 34:485-490
  27. Taguchi I, Kiyohara H, Matsumoto T, Yamada H. 2004. Structure of oligosaccharide side chains of an intestinal immune system modulating arabinogalatan isolated from rhizomes of Atractylodes lancea DC. Carbohydr Res 339:763-770
  28. Tsuneki H, Ma EL, Kobayashi S, Sekinazi N, Maekawa K, Sasaoka T, Wang MW, Kimura I. 2005. Antiangiogenic activity of ${\beta}$-eudesmol in vitro and in vivo. Eur J Pharmacol 512:105-115
  29. Williams KV, Mullen ML, Kelley DE, Wing RR. 1998. The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes. Diabetes Care 21:2-8
  30. World Health Organization. 2014. Global Status Report on Noncommunicable Diseases 2014. World Health Organization
  31. Yang YR, Kim HL, Park YK. 2008. Effects of onion kimchi extract supplementation on blood glucose and serum lipid contents in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 37:445-451