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http://dx.doi.org/10.9799/ksfan.2020.33.5.544

Effects of Atractylodes lancea on Plasma Glucose and Lipid Profile in Streptozotocin Induced Diabetic Rats  

Han, Hye Kyoung (Dept. of Food and Nutrition, College of Natural Science, Duksung Women's University)
Choi, Eun Young (Dept. of Food and Nutrition, KyungBuk College)
Publication Information
The Korean Journal of Food And Nutrition / v.33, no.5, 2020 , pp. 544-550 More about this Journal
Abstract
The purpose of this study was to examine the effects of Atractylodes lancea (A.l.) in a dose-dependent manner on lipid levels and plasma glucose in diabetic rats induced with streptozotocin (STZ). The Sprague-Dawley rats were randomly classified into five groups: normal, STZ-control and three experimental groups [A.l.-1, diabetic treated with ethanolic extract of A.l. (1 g/kg b.w.), A.l.-2, diabetic administered with ethanolic extract of A.l. (2 g/kg b.w.), and A.l.-3, diabetic administered with ethanolic extract of A.l. (3 g/kg b.w.)]. The normal and STZ-control group were fed an AIN-93 diet and the three experimental groups were administered with A.l. extract at doses of 1, 2, and 3 g/kg b.w./day, respectively, for 14 days. The plasma glucose levels in all the experimental groups were significantly lower than the STZ-control group after 14 days of treatment. The total cholesterol of the A.l.-3 and triglyceride levels, atherogenic index (AI) of all three experimental groups were significantly lower than the STZ-control group. The ALT and AST activities at A.l.-2, A.l.-3 were significantly lower than the STZ-control group. This result that demonstrate the administration of Atractylodes lancea can reduce hyperglycemia and hyperlipidemia risk in diabetic rats.
Keywords
Atractylodes lancea; diabetic rats; hypoglycemic effect; hyperlipidema risk;
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