Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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The Flower Extract of Abelmoschus manihot (Linn.) Increases Cyclin D1 Expression and Activates Cell Proliferation

  • Park, Yea-In (Division of Biological Science and Technology, Yonsei University) ;
  • Cha, Yeo-Eun (Division of Biological Science and Technology, Yonsei University) ;
  • Jang, Minsu (Division of Biological Science and Technology, Yonsei University) ;
  • Park, Rackhyun (Division of Biological Science and Technology, Yonsei University) ;
  • Namkoong, Sim (Department of Biochemistry, Kangwon National University) ;
  • Kwak, Jongbock (ALL IN ON) ;
  • Jang, Ik-Soon (Division of Analytical Science, Korea Basic Science Institute) ;
  • Park, Junsoo (Division of Biological Science and Technology, Yonsei University)
  • Received : 2020.02.14
  • Accepted : 2020.03.04
  • Published : 2020.07.28
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Abstract

Abelmoschus manihot (Linn.) is a medicinal herbal plant that is commonly used to treat chronic kidney disease and hepatitis. However, its effect on cell proliferation has not been clearly revealed. In this report, we sought to determine the effect of the flower extract of A. manihot (FA) on cell proliferation. Based on our findings, FA increased the proliferation of human diploid fibroblast (HDF) and HEK293 cells. Through cell cycle analysis, FA was found to increase the number of HDF cells in the S phase and G2/M phase. FA also increased the expression of cyclin D1 and enhanced the migration of HDF cells. By administering FA to HDF cells with ≥30 passages, a decrease in the number of senescence-associated β galactosidase-positive cells was observed, thereby indicating that FA can ameliorate cellular senescence. Collectively, our findings indicate that FA increases cyclin D1 expression and regulates cell proliferation.

Keywords

References

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