Korean Journal of Radiology

  • 제21권8호
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  • Pages.967-977
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  • 2020
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
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Tube Voltage, DNA Double-Strand Breaks, and Image Quality in Coronary CT Angiography

  • Zhu Xiao Lin (Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University) ;
  • Fan Zhou (Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University) ;
  • U. Joseph Schoepf (Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University) ;
  • Balakrishnan Pillai (Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina) ;
  • Chang Sheng Zhou (Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University) ;
  • Wei Quan (Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University) ;
  • Xue Qin Bao (Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University) ;
  • Guang Ming Lu (Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University) ;
  • Long Jiang Zhang (Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University)
  • 투고 : 2019.12.24
  • 심사 : 2020.03.05
  • 발행 : 2020.08.01
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초록

Objective: To evaluate the effects of tube voltage on image quality in coronary CT angiography (CCTA), the estimated radiation dose, and DNA double-strand breaks (DSBs) in peripheral blood lymphocytes to optimize the use of CCTA in the era of low radiation doses. Materials and Methods: This study included 240 patients who were divided into 2 groups according to the DNA DSB analysis methods, i.e., immunofluorescence microscopy and flow cytometry. Each group was subdivided into 4 subgroups: those receiving CCTA only with different tube voltages of 120, 100, 80, or 70 kVp. Objective and subjective image quality was evaluated by analysis of variance. Radiation dosages were also recorded and compared. Results: There was no significant difference in demographic characteristics between the 2 groups and 4 subgroups in each group (all p > 0.05). As tube voltage decreased, both image quality and radiation dose decreased gradually and significantly. After CCTA, γ-H2AX foci and mean fluorescence intensity in the 120-, 100-, 80-, and 70-kVp groups increased by 0.14, 0.09, 0.07, and 0.06 foci per cell and 21.26, 9.13, 8.10, and 7.13 (all p < 0.05), respectively. The increase in the DNA DSB level in the 120-kVp group was higher than those in the other 3 groups (all p < 0.05), while there was no significant difference in the DSBs levels among these latter groups (all p > 0.05). Conclusion: The 100-kVp tube voltage may be optimal for CCTA when weighing DNA DSBs against the estimated radiation dose and image quality, with further reductions in tube voltage being unnecessary for CCTA.

키워드

과제정보

This work was supported by The National Key Research and Development Program of China (2017YFC0113400 for L.J.Z.).

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