Journal of fish pathology (한국어병학회지)

The Korean Society of Fish Pathology (한국어병학회)
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Effects of intramuscular injection of Taurine-FTM on anti-hepatotoxicity and innate immunity in olive flounder, paralichthys olivaceus

Taurine-FTM의 근육 주사가 넙치의 간 독성 완화와 선천성 면역에 미치는 효과

  • Choi, Jae Hyeok (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University) ;
  • Jung, Sang Mok (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University) ;
  • Kang, In Sung (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University) ;
  • Choi, Sanghoon (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
  • 최재혁 (군산대학교 해양과학대학 수산생명의학과) ;
  • 정상목 (군산대학교 해양과학대학 수산생명의학과) ;
  • 강인성 (군산대학교 해양과학대학 수산생명의학과) ;
  • 최상훈 (군산대학교 해양과학대학 수산생명의학과)
  • Received : 2020.05.27
  • Accepted : 2020.06.17
  • Published : 2020.06.30
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Abstract

In the study, we investigated the effect of Taurine-FTM, which is a commercially available fishery nutritional supplements complex, on anti-hepatotoxicity stressed with thioacetamide (TAA) and innate immune responses in olive flounder. To investigate the change in liver toxicity, firstly, TAA (30 ppm/100 g of fish) was intraperitoneally (i.p.) administered 12 hr after the intramuscular (i.m.) injection of Taurine-FTM (0.02 ml/100 g of fish)(Taurine/TAA). Secondly, Taurine-FTM was i.m. injected 24 hr after the administration of TAA (TAA/Taurine). Finally, TAA was administered simultaneously with Taurine-FTM (TAA+Taurine). All blood samples were collected 24 hr after injection. GOT level in group Taurine/TAA appeared similar to the control, whereas group TAA/Taurine and TAA+Taurine showed significantly increased (p<0.05) levels compared to the control. In GPT level, group Taurine/TAA and TAA/Taurine showed elevated levels compared to the control, whereas no significant difference was observed between group TAA+Taurine and the control. Serum ACH50 activity was significantly (p<0.05) augmented 24 hr after Taurine-FTM injection compared to the control group, whereas no significant increase was observed 48 hr after Taurine-FTM injection. On the other hand, serum lysozyme activity elevated in an acute stressed condition appeared significantly down-regulated 24 and 48 hr after Taurine-FTM injection compared to the control. In conclusion, i.m. injected Taurine-FTM augmented flounder serum complement activity and decreased a possible handling stress resulting in reducing a serum lysozyme activity and recovering hepatotoxicity. Thus, it is assumed that i.m. injection of Taurine-FTM mixed with antibiotics or available vaccines could be utilized as an anti-hepatotoxic recipe in fish culture industry.

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References

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