대한한의학방제학회지 (Herbal Formula Science)

  • 제28권2호
  • /
  • Pages.169-177
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  • 2020
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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선복화 에탄올 추출물의 급성 독성 연구

Safety Evaluation of Ethanol Extract of Inulae Flos : Single-dose Oral Toxicity Study in Mice

  • 권다혜 (동의대학교 항노화연구소) ;
  • 김민영 (동의대학교 항노화연구소) ;
  • 황보현 (부산대학교 분자생물학과) ;
  • 지선영 (부산대학교 분자생물학과) ;
  • 박철 (동의대학교 동의지천교양대학 기초과학교양학부) ;
  • 최영현 (동의대학교 항노화연구소) ;
  • 홍수현 (동의대학교 항노화연구소)
  • Kwon, Da Hye (Anti-Aging Research Center, Dong-eui University) ;
  • Kim, Min Young (Anti-Aging Research Center, Dong-eui University) ;
  • Hwangbo, Hyun (Department of Molecular Biology, Pusan National University) ;
  • Ji, Seon Yeong (Department of Molecular Biology, Pusan National University) ;
  • Park, Cheol (Division of Basic Sciences, College of Liberal Studies, Dong-eui University) ;
  • Choi, Yung Hyun (Anti-Aging Research Center, Dong-eui University) ;
  • Hong, Su Hyun (Anti-Aging Research Center, Dong-eui University)
  • 투고 : 2020.03.20
  • 심사 : 2020.05.28
  • 발행 : 2020.05.31
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초록

Objectives : This experiment was designed to assess the single oral toxicity of Ethanol Extract Inulae Flos (IF) ethanol extracts. IF is one of the important herbs to remove phlegmy which is the viscous turbid pathological product that can accumulate in the body, causing a variety of diseases. Nevertheless, there has been a lack of research on the pharmacology toxicity of IF. Methods : In this study, IF was orally administered to 5 weeks ICR mice as an oral dose of 2,000 or 3,000 or 5,000 mg/kg. The condition of the mice was observed for 14 days and their weights were measured every two days. Results : None of the mice died for 14 days. The abnormal clinical symptoms and anatomical signs of toxicity were not found in any treatment groups. The gain of net body weight was observed. There was also no significant difference in the organ weight. The serum biochemistry and hematological analysis showed a decrease in BUN, red blood cells, white blood cells and platelets although within the normal ranges. Conclusions : These results suggest that the 50% lethal dose of IF is more than 5,000 mg/kg. This could be thought that IF is a safe drug without acute toxicity and side effects. However, IF showed some weight loss and change in blood test, so it will need to be careful when using it for high doses.

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참고문헌

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