The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Review on Amorfrutin of Licorice for Type2 Diabetes Mellitus

감초의 amorfrutin성분과 당뇨 치료 효과에 대한 고찰

  • Han, Juhee (Dept. of Korean Medicine, College of Korean Medicine, Woosuk University) ;
  • Heo, Hyemin (Dept. of Korean Medicine, College of Korean Medicine, Woosuk University) ;
  • Jeong, Minjeong (Dept. of Pediatrics, College of Korean Medicine, Woosuk University) ;
  • Kim, Hongjun (Dept. of Prescription, College of Korean Medicine, Woosuk University) ;
  • Jang, Insoo (Dept. of Internal Medicine, College of Korean Medicine, Woosuk University)
  • 한주희 (우석대학교 한의과대학 한의학과) ;
  • 허혜민 (우석대학교 한의과대학 한의학과) ;
  • 정민정 (우석대학교 한의과대학 한방소아과학 교실) ;
  • 김홍준 (우석대학교 한의과대학 방제학교실) ;
  • 장인수 (우석대학교 한의과대학 한방내과학교실)
  • Received : 2020.11.20
  • Accepted : 2020.12.22
  • Published : 2020.12.30
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Abstract

Objective: The purpose of this study was to investigate the effect of amorfrutin of licorice for Type2 diabetes mellitus. Method: The PubMed, CNKI, Wanfang, OASIS, NDSL, J-STAGE, and CiNii databases were searched from the beginning of the search to September 20, 2020, with no limits on language. Extractions and selections from the literature were made by two authors. The study included in vivo experiments with amorfrutins in high-fat diet-induced obesity C57BL/6 mice and leptin receptor-deficient db/db mice and in silico studies. Results & Conclusion: Four studies were finally selected. We confirmed that amorfrutin treatment considerably improved insulin sensitivity and glucose tolerance and reduced plasma insulin and glucose. Amorfrutins bind to and selectively activate Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), which plays an important role in glucose metabolism. Amorfrutins also strongly bind to the glucagon receptor (GCGR) and work as antagonist. Using the amorfrutins from licorice could therefore be helpful in treating type2 diabetes mellitus.

Keywords

References

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