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http://dx.doi.org/10.22246/jikm.2020.41.6.1078

Review on Amorfrutin of Licorice for Type2 Diabetes Mellitus  

Han, Juhee (Dept. of Korean Medicine, College of Korean Medicine, Woosuk University)
Heo, Hyemin (Dept. of Korean Medicine, College of Korean Medicine, Woosuk University)
Jeong, Minjeong (Dept. of Pediatrics, College of Korean Medicine, Woosuk University)
Kim, Hongjun (Dept. of Prescription, College of Korean Medicine, Woosuk University)
Jang, Insoo (Dept. of Internal Medicine, College of Korean Medicine, Woosuk University)
Publication Information
The Journal of Internal Korean Medicine / v.41, no.6, 2020 , pp. 1078-1088 More about this Journal
Abstract
Objective: The purpose of this study was to investigate the effect of amorfrutin of licorice for Type2 diabetes mellitus. Method: The PubMed, CNKI, Wanfang, OASIS, NDSL, J-STAGE, and CiNii databases were searched from the beginning of the search to September 20, 2020, with no limits on language. Extractions and selections from the literature were made by two authors. The study included in vivo experiments with amorfrutins in high-fat diet-induced obesity C57BL/6 mice and leptin receptor-deficient db/db mice and in silico studies. Results & Conclusion: Four studies were finally selected. We confirmed that amorfrutin treatment considerably improved insulin sensitivity and glucose tolerance and reduced plasma insulin and glucose. Amorfrutins bind to and selectively activate Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), which plays an important role in glucose metabolism. Amorfrutins also strongly bind to the glucagon receptor (GCGR) and work as antagonist. Using the amorfrutins from licorice could therefore be helpful in treating type2 diabetes mellitus.
Keywords
amorfrutin; licorice; Type2 diabetes mellitus; $PPAR{\gamma}$;
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Times Cited By KSCI : 5  (Citation Analysis)
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