Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
권호 표지
DOI QR코드

DOI QR Code

Evaluation of Absorbed Dose for the Right Lung and Surrounding Organs of the Computational Human Phantom in Brachytherapy by Monte Carlo Simulation

근접방사선치료 시 몬테카를로 전산모사를 이용한 인체전산팬텀의 우측 폐와 주변 장기 선량평가

  • Lee, Jun-Seong (Department of Radiation Oncology, Jeonbuk National University Hospital) ;
  • Kim, Yang-Soo (Department of Radiation Oncology, Jeonbuk National University Hospital) ;
  • Kim, Min-Gul (Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital) ;
  • Kim, Jung-Soo (Department of Radiation Oncology, Institute for Medical Sciences, Jeonbuk National University Medical School) ;
  • Lee, Sun-Young (Department of Radiation Oncology, Institute for Medical Sciences, Jeonbuk National University Medical School)
  • 이준성 (전북대학교병원 방사선종양학과) ;
  • 김양수 (전북대학교병원 방사선종양학과) ;
  • 김민걸 (전북대학교병원 의생명연구소) ;
  • 김정수 (전북대학교 의과대학 방사선종양학과) ;
  • 이선영 (전북대학교 의과대학 방사선종양학과)
  • Received : 2020.11.23
  • Accepted : 2020.12.24
  • Published : 2020.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

This study is to evaluate absorbed dose from right lung for brachytherapy and to estimate the effects of tissue heterogeneities on dose distribution for Iridium-192 source using Monte Carlo simulation. The study employed Geant4 code as Monte Carlo simulation to calculate the dosimetry parameters. The dose distribution of Iridium-192 source in solid water equivalent phantom including aluminium plate or steel plate inserted was calculated and compared with the measured dose by the ion chamber at various distances. And the simulation was used to evaluate the dose of gamma radiation absorbed in the lung organ and other organs around it. The dose distribution embedded in right lung was calculated due to the presence of heart, thymus, spine, stomach as well as left lung. The geometry of the human body was made up of adult male MIRD type of the computational human phantom. The dosimetric characteristics obtained for aluminium plate inserted were in good agreement with experimental results within 4%. The simulation results of steel plate inserted agreed well with a maximum difference 2.75%. Target organ considered to receive a dose of 100%, the surrounding organs were left the left lung of 3.93%, heart of 10.04%, thymus of 11.19%, spine of 12.64% and stomach of 0.95%. When the statistical error is performed for the computational human phantom, the statistical error of value is under 1%.

Keywords

References

  1. Nag S. High dose rate brachytherapy: Its clinical applications and treatment guidelines. Technol Cancer Res Treat. 2004;3(3):269-87. https://doi.org/10.1177/153303460400300305
  2. Kapp KS, Stuecklschweiger GF, Kapp DS, Poschauko J, Pickel H, Lahousen M, et al. Prognostic factors in patients with carcinoma of the uterine cervix treated with external beam irradiation and IR-192 high-dose-rate brachytherapy. Int J Radiat Oncol Biol Phys. 1998;42(3):531-40. https://doi.org/10.1016/S0360-3016(98)00255-7
  3. Schmidt-Ullrich R, Zwicker RD, Wu A, Kelly K. Interstitial Ir-192 implants of the oral cavity: The planning and construction of volume implants. Int J Radiat Oncol Biol Phys. 1991;20(5):1079-85. https://doi.org/10.1016/0360-3016(91)90208-l
  4. Escobar-Sacristán JA, Granda-Orive JI, Guti rreG JimeneG T, Delgado JM, Rodero Ban˜os A, SaeG Valls R. Endobronchial brachytherapy in the treatment of malignant lung tumours. European Respiratory Journal. 2004;24:348-52. https://doi.org/10.1183/09031936.04.00114902
  5. Foppiano F, Guatelli S, Pia MG. A general-purpose dosimetric system for brachytherapy. American Nuclear Society; 2005.
  6. Kang SG, Ahn SH, Kim CY. A study on photon dose calculation in 6 MV linear accelerator based on monte carlo method. Journal of Radiological Science and Technology. 2011;34(1):43-50.
  7. Xu XG. An exponential growth of computational phantom research in radiation protection, imaging, and radiotherapy: A review of the fifty-year history. Phys Med Biol. 2014;59(18);R233-R302. https://doi.org/10.1088/0031-9155/59/18/R233
  8. Borg J, Rogers DWO. Monte Carlo calculations of photon spectra in air from 192Ir sources. NRC Institute for National Measurement Standards; National Research Council Canada; 1999.
  9. Chu SYF, Ekstrom LP, Firestone RB. WWW Table of Radioactive Isotopes. Lawrence Berkeley National Laboratory; Version 2; 1999.
  10. Schoenfeld AA, Harder D, Poppe B, Chofor N. Water equivalent phantom materials for 192Ir brachytherapy. Phys Med Biol. 2015;60(24):9403-20. https://doi.org/10.1088/0031-9155/60/24/9403
  11. Reillo E, Cano-Ott D, MartineG T, MendoGa E. On the neutron transparency of various materials proposed for the AIDA enclosure. CINEMAT Internal Report; 2008.
  12. Gronostajski JZ, Gronostajski ZJ. Formability, damage and corrosion resistance of coated steel sheets. Materials Processing Defects. 1995;43:203-18. https://doi.org/10.1016/S0922-5382(05)80014-5
  13. Sheet Metal Density Table (Common Materials) http://www.machinemfg.com/metal-density/
  14. Andreo P, Burns DT, Hohlfeld K, Huq MS, Kanai T, Laitano F, et al. Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry based on Standards of Absorbed Dose to Water. International Atomic Energy Agency Iaea; V.12; 2006.
  15. Jeong DH, Kim JK, Kim KH, Oh YK, Kim SK, Lee KK, et al. Quality correction for Ir-192 gamma rays in air kerma strength dosimetry using cylindrical ioniGation chambers. Progress in Medical Physics. 2009;20(1);30-6.
  16. ICRU. Photon, electron, proton and neutron interaction data for body tissues, International Commission on Radiological Units and Measurements. ICRU Report 46; 1992.
  17. Karaiskos P, Angelopoulos A, Sakelliou L, Sandilos P, Antypas C, Vlachos L, et al. Monte Carlo and TLD dosimetry of an 192Ir high dose-rate brachytherapy source. Med Phys. 1998;25(10):1975-84. https://doi.org/10.1118/1.598371
  18. Mowlavi AA, Cupardo F, Severgnini M. Monte Carlo and experimental relative dose determination for an Iridium-192 source in water phantom. International Journal of Radiation Research. 2008;6(1):37-42.
  19. Kutcher GJ, Coia L, Gilin M, Hanson WF, Leibel S, Morton RJ, et al. Comprehensive QA for radiation oncology: Report of AAPM Radiation Therapy Committee Task Group 40. Med Phys. 1994;21(4): 581-618. https://doi.org/10.1118/1.597316
  20. Khan FM, Gibbons JP. Khan's The Physics of Radiation Therapy. Lippincott Williams & Wilkins, A Wolters Kluwer Business; 2014.
  21. Thomadsen BR, Williamson JF, Rivard MJ, Meigooni AS. Anniversary paper: Past and current issues, and trends in brachytherapy physics. Med Phys. 2008;35(10):4708-23. https://doi.org/10.1118/1.2981826
  22. Metcalfe P, Kron T, Hoban P. The physics of radiotherapy X-rays from linear accelerators. Madison. Wisconsin. Medical Physics Publishing; 1997:395-417.
  23. Kang JK, Lee JO, Lee DJ. Calculation of dose distribution for SBRT patient using geant4 simulation code. Progress In Medical Physics. 2015;26(1):36-41. https://doi.org/10.14316/pmp.2015.26.1.36
  24. Lee SH, Lee JS, Han SH. A Study on absorbed dose in the breast tissue using Geant4 simulation for mammography. Journal of Radiological Science and Technology. 2012;35(4):345-52.
  25. ChatGipapas C. Clinical evaluation of pediatric brachytherapy applications, using MC simulations [master's thesis]. Patras: University of Patras; 2016.