한방비만학회지 (Journal of Korean Medicine for Obesity Research)

  • 제20권2호
  • /
  • Pages.88-96
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  • 2020
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  • 1976-9334(pISSN)
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  • 2288-1522(eISSN)
한방비만학회 (The Society of Korean Medicine for obesity Research)
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힐초근(纈草根) 메탄올 추출물이 고지혈증 유발 생쥐의 지질대사에 미치는 영향

Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice

  • 박선미 (동의대학교 한의과대학 한방내과) ;
  • 김영균 (동의대학교 한의과대학 한방내과) ;
  • 유선애 (동의대학교 한의과대학 한방소아과) ;
  • 조성우 (동의대학교 한의과대학 한방재활의학과) ;
  • 이명화 (동의대학교 한의과대학 한방내과) ;
  • 임재은 (동의대학교 한의과대학 침구의학과) ;
  • 김경민 (동의대학교 한의과대학 한방내과)
  • Park, Sun Mi (Department of Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Kim, Young Kyun (Department of Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Yu, Sun Ae (Department of Pediatrics, College of Oriental Medicine, Dong-Eui University) ;
  • Cho, Sung Woo (Department of Korean Rehabilitation Medicine of Korean Medicine, Dong-Eui University) ;
  • Lee, Myeong Hwa (Department of Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Lim, Jae Eun (Department of Acupuncture & Moxibustion Meridian & Acupoint, College of Korean Medicine, Dong-Eui University) ;
  • Kim, Kyoung Min (Department of Internal Medicine, College of Korean Medicine, Dong-Eui University)
  • 투고 : 2020.10.31
  • 심사 : 2020.11.23
  • 발행 : 2020.12.30
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초록

Objectives: This study was designed to investigate the effects of Valerianae Radix et Rhizoma Methanol Extract (VRME) on serum lipid levels in a high-fat diet-induced hyperlipidemic mice. Methods: Each 8 C57BL/6 mice were randomly assigned to normal diet group, high-fat diet control group, high-fat diet plus 100 mg/kg/day of VRME group. In order to induce hyperlipidemia, high-fat diets were supplied to control group and VRME group for four weeks. Normal diet group were supplied with general feed for four weeks. After that control group supplied only high-fat diets as feed, VRME group received oral administration of VRME with high-fat diets for three weeks. and normal diet group were supplied with general feed for three weeks. After seven weeks, the changes in the body weight, the plasma levels of total cholesterol, triglyceride, high density lipoprotein-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose in serum were measured. Results: In our results, VRME did not affects weight gain, serum AST and ALT in high-fat diet-induced hyperlipidemic mice. Oral administration of VRME lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. and oral administration of VRME lowered blood glucose significantly. Conclusions: These results suggest that VRME could act as a potent antihyperlipidemic in therapeutics for hyperlipidemia.

키워드

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