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Beneficial Effect of Cordyceps militaris on Exercise Performance via Promoting Cellular Energy Production

  • Choi, Eunhyun (Translational Research Division, Biomedical Institute of Mycological Resource, International St. Mary's Hospital and College of Medicine, Catholic Kwandong University) ;
  • Oh, Junsang (Translational Research Division, Biomedical Institute of Mycological Resource, International St. Mary's Hospital and College of Medicine, Catholic Kwandong University) ;
  • Sung, Gi-Ho (Translational Research Division, Biomedical Institute of Mycological Resource, International St. Mary's Hospital and College of Medicine, Catholic Kwandong University)
  • Received : 2020.06.05
  • Accepted : 2020.09.28
  • Published : 2020.12.31

Abstract

Cordyceps militaris has been reported to the diverse pharmaceutical effects including cancer, inflammatory diseases, and bacteria or virus infection. However, the effect of C. militaris on exercise performance has not yet been elucidated. In this study, we investigated the beneficial effect of C. militaris on exercise performance. To evaluate exercise performance, we prepared C. militaris ethyl acetate extract (CMEE) and conducted grip strength tests every week after administration. Additionally, blood samples were collected at the end of the experiment for biochemical analysis. The administration of CMEE slightly increased grip strength, and this result was similar to the red ginseng treated group. According to the result of biochemical analysis, CMEE had an effect on the biomarkers related to ATP generation pathway but had little influence on the muscle fatigue related biomarkers. Therefore, C. militaris has the possibility of improving exercise performance, which could be associated with the increase in ATP production rather than the decrease in muscle fatigue during exercise.

Keywords

References

  1. Warburton DE, Nicol CW, Bredin SS. Health benefits of physical activity: the evidence. CMAJ. 2006;174:801-809. https://doi.org/10.1503/cmaj.051351
  2. Loureiro A, Veloso S. Green exercise, health and well-being. In: Fleury-Bahi G, Pol E, Navarro O, editors. Handbook of environmental psychology and quality of life research. Cham (Switzerland): Springer; 2017. p. 149-169.
  3. Penedo FJ, Dahn JR. Exercise and well-being: a review of mental and physical health benefits associated with physical activity. Curr Opin Psychiatry. 2005;18:189-193. https://doi.org/10.1097/00001504-200503000-00013
  4. Jagim AR, Harty PS, Camic CL. Common ingredient profiles of multi-ingredient pre-workout supplements. Nutrients. 2019;11:254. https://doi.org/10.3390/nu11020254
  5. Park JG, Son YJ, Lee TH, et al. Anticancer efficacy of Cordyceps militaris ethanol extract in a xenografted leukemia model. Evid Based Complement Alternat Med. 2017;2017:8474703.
  6. Shin S, Kwon J, Lee S, et al. Immunostimulatory effects of Cordyceps militaris on macrophages through the enhanced production of cytokines via the activation of NF-kappaB. Immune Netw. 2010;10:55-63. https://doi.org/10.4110/in.2010.10.2.55
  7. Li XT, Li HC, Li CB, et al. Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris. Am J Chin Med. 2010;38:1093-1106. https://doi.org/10.1142/S0192415X10008494
  8. Dong CH, Yang T, Lian T. A comparative study of the antimicrobial, antioxidant, and cytotoxic activities of methanol extracts from fruit bodies and fermented mycelia of caterpillar medicinal mushroom Cordyceps militaris (Ascomycetes). Int J Med Mushrooms. 2014;16:485-495. https://doi.org/10.1615/IntJMedMushrooms.v16.i5.70
  9. Song J, Wang Y, Teng M, et al. Studies on the antifatigue activities of Cordyceps militaris fruit body extract in mouse model. Evid Based Complement Alternat Med. 2015;2015:174616.
  10. Wan JJ, Qin Z, Wang PY, et al. Muscle fatigue: general understanding and treatment. Exp Mol Med. 2017;49:e384. https://doi.org/10.1038/emm.2017.194
  11. Huang WC, Chiu WC, Chuang HL, et al. Effect of curcumin supplementation on physiological fatigue and physical performance in mice. Nutrients. 2015;7:905-921. https://doi.org/10.3390/nu7020905
  12. Kim H, Park S, Han DS, et al. Octacosanol supplementation increases running endurance time and improves biochemical parameters after exhaustion in trained rats. J Med Food. 2003;6:345-351. https://doi.org/10.1089/109662003772519903
  13. Dalla Corte CL, de Carvalho NR, Amaral GP, et al. Antioxidant effect of organic purple grape juice on exhaustive exercise. Appl Physiol Nutr Metab. 2013;38:558-565. https://doi.org/10.1139/apnm-2012-0230
  14. Ping FW, Keong CC, Bandyopadhyay A. Effects of acute supplementation of Panax ginseng on endurance running in a hot & humid environment. Indian J Med Res. 2011;133:96-102.
  15. Shin EJ, Jo S, Choi S, et al. Red ginseng improves exercise endurance by promoting mitochondrial biogenesis and myoblast differentiation. Molecules. 2020;25:865. https://doi.org/10.3390/molecules25040865
  16. Takeshita H, Yamamoto K, Nozato S, et al. Modified forelimb grip strength test detects agingassociated physiological decline in skeletal muscle function in male mice. Sci Rep. 2017;7:42323. https://doi.org/10.1038/srep42323
  17. Vollestad NK, Sejersted OM. Biochemical correlates of fatigue. A brief review. Eur J Appl Physiol Occup Physiol. 1988;57:336-347. https://doi.org/10.1007/BF00635993
  18. Tung YT, Hsu YJ, Liao CC, et al. Physiological and biochemical effects of intrinsically high and low exercise capacities through multiomics approaches. Front Physiol. 2019;10:1201. https://doi.org/10.3389/fphys.2019.01201
  19. Layzer RB. Muscle metabolism during fatigue and work. Baillieres Clin Endocrinol Metab. 1990;4:441-459. https://doi.org/10.1016/S0950-351X(05)80064-3
  20. Ke R, Xu Q, Li C, et al. Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism. Cell Biol Int. 2018;42:384-392. https://doi.org/10.1002/cbin.10915
  21. Richter EA, Hargreaves M. Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol Rev. 2013;93:993-1017. https://doi.org/10.1152/physrev.00038.2012
  22. Morales-Alamo D, Guerra B, Santana A, et al. Skeletal muscle pyruvate dehydrogenase phosphorylation and lactate accumulation during sprint exercise in normoxia and severe acute hypoxia: effects of antioxidants. Front Physiol. 2018;9:188. https://doi.org/10.3389/fphys.2018.00188
  23. Guimaraes-Ferreira L. Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles. Einstein (Sao Paulo). 2014;12:126-131. https://doi.org/10.1590/S1679-45082014RB2741
  24. Thomas AW, Davies NA, Moir H, et al. Exerciseassociated generation of PPARgamma ligands activates PPARgamma signaling events and upregulates genes related to lipid metabolism. J Appl Physiol. 2012;112:806-815. https://doi.org/10.1152/japplphysiol.00864.2011

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  1. Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity vol.10, pp.11, 2020, https://doi.org/10.3390/foods10112634