디지털융복합연구 (Journal of Digital Convergence)

  • 제18권1호
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  • Pages.241-247
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  • 2020
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  • 2713-6434(pISSN)
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  • 2713-6442(eISSN)
한국디지털정책학회 (The Society of Digital Policy and Management)
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전자파에 노출된 생쥐에서 운동량에 따른 뇌의 유전자 변화

The Gene Expression Level Differences associated with Exercise in the Mouse Brain exposed to Radiofrequency Radiation

  • 투고 : 2019.11.22
  • 심사 : 2020.01.20
  • 발행 : 2020.01.28
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초록

전자파 노출이 자발운동에 따른 뇌의 유전자 발현에 미치는 영향을 10 주간 4그룹 즉, 정상 그룹, 자발운동 그룹, 전자파 노출 그룹, 전자파 노출 및 자발운동 그룹으로 나누어 조사하였다. 선조체(striata)와 시상하부(hypothalamus)에서 RT-PCR을 수행하였으며, 타이로신수산화효소(TH), FoxO3a, AMPKα, mRNA 발현을 조사하였다. 선조체에서 TH mRNA 발현은 자발운동과 전자파 노출 조건에서 각각 감소하였고, 전자파 노출 및 자발운동 그룹에서 더 많이 감소되었다. 이 결과는 전자파 노출 및 자발운동 그룹에서의 운동량 감소가 선조체에서 도파민이 감소할 수 있음을 시사한다. 선조체에서 FoxO3a mRNA 발현은 자발운동 그룹에서 증가했지만, 전자파 노출 및 자발운동 그룹은 현저히 감소했다. 시상하부에서는 TH mRNA 유전자 발현은 전자파 노출을 받은 자발운동 그룹에서 감소가 유의했으며, FoxO3a mRNA는 발현의 현저한 증가가 있었다. 전자파가 기억력에 미치는 영향도 밝히기 위해 해마에서의 여러 단백질들의 발현을 추후 조사할 것이다.

The effect of radiofrequency radiation (RF) exposure on mouse associated with the exercise was investigated in the brain at the molecular level. The expression of tyrosine hydroxylase(TH), FoxO3a, AMPKα and mRNA was investigated by real-time RT-PCR in striatum and the hypothalamus. In the striatum, TH mRNA expression was decreased in the exercise and RF exposure group. FoxO3a mRNA expression was significantly increased in the spontaneous exercise group and a significant decrease was observed in the RF exposure and spontaneous exercise group. In the hypothalamus, TH mRNA expression was significantly decreased in the RF exposure and spontaneous exercise group. But, FoxO3a mRNA expression was significantly increased in the RF exposure and spontaneous exercise group. We will further investigate the expression of protein molecules in the hippocampus of the brain to reveal the effects of RF radiation on memory.

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