Molecules and Cells

  • 제42권11호
  • /
  • Pages.747-754
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  • 2019
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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Cellular and Molecular Links between Autoimmunity and Lipid Metabolism

  • Ryu, Heeju (Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kim, Jiyeon (Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kim, Daehong (Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Lee, Jeong-Eun (Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Chung, Yeonseok (Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, Seoul National University)
  • 투고 : 2019.08.29
  • 심사 : 2019.11.03
  • 발행 : 2019.11.30
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초록

The incidence of atherosclerosis is higher among patients with several autoimmune diseases such as psoriasis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). It is well documented that innate immune cells including macrophages and dendritic cells sense lipid species such as saturated fatty acids and oxidized low-density lipoprotein and produce pro-inflammatory cytokines and chemokines. However, whether a hyperlipidemic environment also impacts autoimmune T cell responses has been unclear. Among $CD4^+$ T cells, Th17 and follicular helper T (Tfh) cells are known to play pathogenic roles in the development of hyperlipidemia-associated autoimmune diseases. This review gives an overview of the cellular and molecular mechanisms by which dysregulated lipid metabolism impacts the pathogenesis of autoimmune diseases, with specific emphasis on Th17 and Tfh cells.

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참고문헌

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  2. Elevated expression of FABP4 is associated with disease activity in rheumatoid arthritis patients vol.14, pp.15, 2019, https://doi.org/10.2217/bmm-2020-0284
  3. Lipid Profiles in Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis: A Cross-sectional Analysis vol.27, pp.4, 2019, https://doi.org/10.4078/jrd.2020.27.4.261
  4. The Effect of a Persian Herbal Medicine Compound on the Lipid Profiles of Patients with Dyslipidemia: A Randomized Double-Blind Placebo-Controlled Clinical Trial vol.2021, 2019, https://doi.org/10.1155/2021/6631963
  5. Clinical Characteristics of Lipid Metabolism in Untreated Patients with Anti-MDA5 Antibody-Positive vol.14, 2019, https://doi.org/10.2147/ijgm.s315885
  6. Association of the ENPP1/ENTPD1 Polymorphisms in Hemodialysis Patients vol.14, 2021, https://doi.org/10.2147/ijgm.s332911
  7. Inhibition of phospholipases suppresses progression of psoriasis through modulation of inflammation vol.246, pp.11, 2019, https://doi.org/10.1177/1535370221993424
  8. Dexamethasone reduces autoantibody levels in MRL/lpr mice by inhibiting Tfh cell responses vol.25, pp.17, 2021, https://doi.org/10.1111/jcmm.16785
  9. The role of high‐density lipoprotein in the regulation of the immune response: implications for atherosclerosis and autoimmunity vol.164, pp.2, 2019, https://doi.org/10.1111/imm.13348