생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제26권2호
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  • Pages.33-38
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  • 2019
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

정신장애의 진화유전학적 모델

Evolutionary Genetic Models of Mental Disorders

  • 박한선 (서울대학교 사회과학대학 인류학과)
  • Park, Hanson (Department of Anthropology, Seoul National University College of Social Science)
  • 투고 : 2019.04.08
  • 심사 : 2019.05.29
  • 발행 : 2019.10.31
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초록

Psychiatric disorder as dysfunctional behavioural syndrome is a paradoxical phenomenon that is difficult to explain evolutionarily because moderate prevalence rate, high heritability and relatively low fitness are shown. Several evolutionary genetic models have been proposed to address this paradox. In this paper, I explain each model by dividing it into selective neutrality, mutation-selection balance, and balancing selection hypothesis, and discuss the advantages and disadvantages of them. In addition, the feasibility of niche specialization and frequency dependent selection as the plausible explanation about the central paradox is briefly discussed.

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참고문헌

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