Browse > Article

Evolutionary Genetic Models of Mental Disorders  

Park, Hanson (Department of Anthropology, Seoul National University College of Social Science)
Publication Information
Korean Journal of Biological Psychiatry / v.26, no.2, 2019 , pp. 33-38 More about this Journal
Abstract
Psychiatric disorder as dysfunctional behavioural syndrome is a paradoxical phenomenon that is difficult to explain evolutionarily because moderate prevalence rate, high heritability and relatively low fitness are shown. Several evolutionary genetic models have been proposed to address this paradox. In this paper, I explain each model by dividing it into selective neutrality, mutation-selection balance, and balancing selection hypothesis, and discuss the advantages and disadvantages of them. In addition, the feasibility of niche specialization and frequency dependent selection as the plausible explanation about the central paradox is briefly discussed.
Keywords
Evolutionary psychiatry; Mental disorder; Balancing selection;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Hunt J, Hodgson D. What is fitness, and how do we measure it. In: Westmeat D, Fox CW, editors. Evolutionary Behavioral Ecology. New York, NY: Oxford University Press;2010. p.46-70.
2 WHO. The World Health Report 2001: Mental health: New Understanding, New Hope. Geneva: World Health Organization;2001.
3 Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005;62:593-602.   DOI
4 Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B, et al. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011;21:655-679.   DOI
5 Smoller JW, Tsuang MT. Panic and phobic anxiety: defining phenotypes for genetic studies. Am J Psychiatry 1998;155:1152-1162.   DOI
6 Maki P, Veijola J, Jones PB, Murray GK, Koponen H, Tienari P, et al. Predictors of schizophrenia--a review. Br Med Bull 2005;73-74:1-15.   DOI
7 Uher R. The role of genetic variation in the causation of mental illness: an evolution-informed framework. Mol Psychiatry 2009;14:1072-1082.   DOI
8 Cross-Disorder Group of the Psychiatric Genomics Consortium. Erratum: Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013;381:1371-1379.   DOI
9 Hettema JM, Prescott CA, Myers JM, Neale MC, Kendler KS. The structure of genetic and environmental risk factors for anxiety disorders in men and women. Arch Gen Psychiatry 2005;62:182-189.   DOI
10 Keller MC, Miller G. Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best? Behav Brain Sci 2006;29:385-404.   DOI
11 Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996;273:1516-1517.   DOI
12 Lander ES. The new genomics: global views of biology. Science 1996;274:536-539.   DOI
13 Park H. Evolutionary Approaches toward Psychiatry. J Korean Neuropsychiatr Assoc 2014;53:347-357.   DOI
14 Estrada-Mena B, Estrada FJ, Ulloa-Arvizu R, Guido M, Mendez R, Coral R, et al. Blood group O alleles in Native Americans: implications in the peopling of the Americas. Am J Phys Anthropol 2010;142:85-94.   DOI
15 Cartwright J. Evolution and Human Behaviour: Darwinian Perspectives on the Human Condition. 3rd ed. New York, NY: Palgrave;2016.
16 Huxley J, Mayr E, Osmond H, Hoffer A. Schizophrenia as a genetic morphism. Nature 1964;204:220-221.   DOI
17 Herron JC, Freeman S. Evolutionary Analysis. 5th ed. Boston, MA: Pearson;2014.
18 Lynch M, Hill WG. Phenotypic evolution by neutral mutation. Evolution 1986;40:915-935.   DOI
19 Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet 1999;22:231-238.   DOI
20 Merila J, Sheldon BC. Genetic architecture of fitness and nonfitness traits: empirical patterns and development of ideas. Heredity (Edinb) 1999;83:103-109.   DOI
21 Crnokrak P, Roff DA. Dominance variance: associations with selection and fitness. Heredity 1995;75:530-540.   DOI
22 Penke L, Denissen JJA, Miller GF. The evolutionary genetics of personality. Eur J Pers 2007;21:549-587.   DOI
23 Keller MC, Coventry WL, Heath AC, Martin NG. Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design. Behav Genet 2005;35:707-721.   DOI
24 Bouchard TJ Jr, Lykken DT, McGue M, Segal NL, Tellegen A. Sources of human psychological differences: the Minnesota study of twins reared apart. Science 1990;250:223-228.   DOI
25 Eaves L, Heath A, Martin N, Maes H, Neale M, et al. Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30,000 study of twins and their relatives. Twin Res 1999;2:62-80.   DOI
26 Keightley PD, Gaffney DJ. Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents. Proc Natl Acad Sci U S A 2003;100:13402-13406.   DOI
27 Eyre-Walker A, Keightley PD. High genomic deleterious mutation rates in hominids. Nature 1999;397:344-347.   DOI
28 Stirling D, Reale D, Roff DA. Selection, structure and the heritability of behaviour. J Evol Biol 2002;15:277-289.   DOI
29 Houle D. Comparing evolvability and variability of quantitative traits. Genetics 1992;130:195-204.   DOI
30 Hughes KA, Burleson MH. Evolutionary causes of genetic variation in fertility and other fitness components. In: Rodgers JL, Rowe DC, iller WB, editors. Genetic Influences on Human Fertility and Sexuality: Theoretical and Empirical Contributions from the Biological and Behavioral Sciences. Norwell, MA: Kluwer Academin Publishers; 2000. p.7-33.
31 Eaves LJ, Heath AC, Neale MC, Hewitt JK, Martin NG. Sex differences and non-additivity in the effects of genes on personality. Twin Res 1998;1:131-137.   DOI
32 Bergmuller R, Taborsky M. Adaptive behavioural syndromes due to strategic niche specialization. BMC Ecol 2007;7:12.   DOI
33 Cannon TD, Keller MC. Endophenotypes in the genetic analyses of mental disorders. Annu Rev Clin Psychol 2006;2:267-290.   DOI
34 Lykken DT, Tellegen A. Is human mating adventitious or the result of lawful choice? A twin study of mate selection. J Pers Soc Psychol 1993;65:56-68.   DOI
35 Figueredo AJ, Sefcek JA, Jones DN. The ideal romantic partner personality. Pers Individ Dif 2006;41:431-441.   DOI
36 Roff DA. Evolutionary Quantitative Genetics. New York, NY: Chapman & Hall;1997.
37 Turelli M, Barton NH. Polygenic variation maintained by balancing selection: pleiotropy, sex-dependent allelic effects and G x E interactions. Genetics 2004;166:1053-1079.   DOI
38 Sulloway FJ. Born to Rebel: Birth Order, Family Dynamics, and Creative Lives. New York, NY: Pantheon Books;1996.
39 Tooby J, Cosmides L. On the universality of human nature and the uniqueness of the individual: the role of genetics and adaptation. J Pers 1990;58:17-67.   DOI
40 Bond AB, Kamil AC. Apostatic selection by blue jays produces balanced polymorphism in virtual prey. Nature 1998;395:594-596.   DOI
41 McGrath J, Saha S, Chant D, Welham J. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev 2008;30:67-76.   DOI
42 Moreira ALR, Van Meter A, Genzlinger J, Youngstrom EA. Review and meta-analysis of epidemiologic studies of adult bipolar disorder. J Clin Psychiatry 2017;78:e1259-e1269.   DOI
43 Manolio TA. Genomewide association studies and assessment of the risk of disease. N Engl J Med 2010;363:166-176.   DOI
44 Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011;43:969-976.   DOI
45 Ng MY, Levinson DF, Faraone SV, Suarez BK, DeLisi LE, Arinami T, et al. Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry 2009;14:774-785.   DOI
46 International Schizophrenia Consortium, Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009;460:748-752.   DOI
47 Wang KS, Liu XF, Aragam N. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. Schizophr Res 2010;124:192-199.   DOI
48 Sullivan PF, Daly MJ, O'Donovan M. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet 2012;13:537-551.   DOI
49 Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003;60:1187-1192.   DOI
50 International Schizophrenia Consortium. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 2008;455:237-241.   DOI
51 Drent PJ, van Noordwijk AJ, van Oers K, de Jong G, Kempenaers B. Contribution of genetics to the study of animal personalities: a review of case studies. Behaviour 2005;142:1185-1206.   DOI
52 Nettle D. The evolution of personality variation in humans and other animals. Am Psychol 2006;61:622-631.   DOI