Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Evolutionary Genetic Models of Mental Disorders

정신장애의 진화유전학적 모델

  • Park, Hanson (Department of Anthropology, Seoul National University College of Social Science)
  • 박한선 (서울대학교 사회과학대학 인류학과)
  • Received : 2019.04.08
  • Accepted : 2019.05.29
  • Published : 2019.10.31
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Abstract

Psychiatric disorder as dysfunctional behavioural syndrome is a paradoxical phenomenon that is difficult to explain evolutionarily because moderate prevalence rate, high heritability and relatively low fitness are shown. Several evolutionary genetic models have been proposed to address this paradox. In this paper, I explain each model by dividing it into selective neutrality, mutation-selection balance, and balancing selection hypothesis, and discuss the advantages and disadvantages of them. In addition, the feasibility of niche specialization and frequency dependent selection as the plausible explanation about the central paradox is briefly discussed.

Keywords

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