Fig. 1. Model and size of nanoemulsion.
Fig. 2. Structure of polyglycerol ester.
Fig. 3. Box-Behnken design, The point at the center of the cube corresponds to the center of the Box-Behnken design, and the point at the middle of each line of the cube corresponds to the IBFact.
Fig. 4. 3D surface graphs. (A-C): particle size of nanoemulsion depending on surfactant, oil, and polyol contents; (D-F): Zeta potential of nanoemulsion depending on surfactant, oil, and polyol contents; (G-I): turbidity of nanoemulsion depending on surfactant, oil, and polyol contents; (J-L): PDI of nanoemulsion depending on surfactant, oil, and polyol contents.
Fig. 5. Response variable values for each sample.
Fig. 6. FIB image of PEG-free nanoemulsion (magnification 50,000x).
Table 1. List of used raw materials
Table 2. Independent variable range of preliminary experiments
Table 3. Independent variables range of PEG-free nanoemulsion optimization experiments
Table 4. Independent variable range for PEG-free nanoemulsion optimization experiments
Table 5. Preliminary experiment by Box-Behnken design
Table 6. Box-Behnken design experiments for PEG-free nanoemulsion optimization
Table 7. ANOVA for the model
Table 8. Coefficient table
Table 9. PEG-free nanomultimate optimization criteria
Table 10. PEG-free nanoemulsion optimal prescription
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