Journal of Korean Traditional Oncology (대한암한의학회지)

Korean Association of Traditional Oncology (대한암한의학회)
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A Case Report of Advanced Non-Small Cell Lung Cancer Patient Treated with Samchilchoongcho-Jung in Conjunction with Alectinib

알렉티닙과 삼칠충초정을 병용하여 호전된 진행성 비소세포성 폐암환자 1례

  • Ko, Myung-hyun (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Myong, Ji-soo (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Park, So-jung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Jeon, Hyung-joon (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Lee, Yeon-weol (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Cho, Chong-kwan (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Yoo, Hwa-seung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
  • 고명현 (대전대학교 둔산한방병원 동서암센터) ;
  • 명지수 (대전대학교 둔산한방병원 동서암센터) ;
  • 박소정 (대전대학교 둔산한방병원 동서암센터) ;
  • 전형준 (대전대학교 둔산한방병원 동서암센터) ;
  • 이연월 (대전대학교 둔산한방병원 동서암센터) ;
  • 조종관 (대전대학교 둔산한방병원 동서암센터) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Received : 2019.05.30
  • Accepted : 2019.06.19
  • Published : 2019.06.30
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Abstract

Objective: The purpose of this study is to report the clinical effectiveness of advanced non-small cell lung cancer (NSCLC) with Samchilchoongcho-Jung (HAD-B1) in conjunction with Alectinib. Methods: The patient was diagnosed with Anaplastic lymphoma kinase (ALK) mutated (2+) non-small cell lung cancer adenocarcinoma stage IV, suffering from edema of lower extremities, dyspnea, pleural effusion, general weakness, insomnia. The patient being treated with Alectinib was treated with Samchilchoongcho-Jung (HAD-B1) for disease control and symptom management. The clinical outcomes were measured by National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Numeral rating scale (NRS) and Eastern Cooperative Oncology Group (ECOG). Results: After treatment, dyspnea and edema of lower extremities was relieved from NRS 7 to 5, and 6 to 1 respectively. And ECOG score of the patient was improved from grade 3 to 2. During and after treatment, we didn't find any severe toxicities on laboratory findings. Conclusion: This case study suggests that Samchilchoongcho-Jung (HAD-B1) may improve symptom relief and life quality of NSCLC patient in conjunction with Alectinib.

Keywords

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Figure 1. Comparison of pleural effusion on Chest X-ray

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Figure 2. Changes of numeral rating scale on clinical symptoms

Table 1. Prescription of Herbal Medicine

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References

  1. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. Lung cancer. In AJCC Cancer Staging Manual. 7th edition. 254-255, 2010
  2. Ministry of Health and Welfare. Korea Central Cancer Registry of National Cancer Center, 2018 Available from URL https://www.cancer.go.kr/lay1/program/S1T211C223/cancer/view.do?cancer_seq=4061&menu_seq=4066 access date 23.05.2019
  3. Sasaki T, Scott J.R, ChirieaccPasi. R, Jannea A. The biology and treatment of EML4-ALK non-small cell lung cancer European. J of Cancer 46(10):1773-1780, July 2010
  4. FDA Professional Drug Information Available from URL https://www.drugs.com/pro/alecensa.html access date 23.05.2019
  5. Ha SJ, Song SI, Park SJ, Jeon HJ, Lee YW, Cho CK, Yoo HS. A Case of Patient with Non-Small Cell Lung Carcinoma Treated with Samchilchoongcho-Jung in Conjunction with Crizotinib. J of Kor. Traditional Oncology 23(1):23-32, 2018 https://doi.org/10.15432/JKTO.2018.23.1.023
  6. National Cancer Institute. Common Terminology Criteria for Adverse Events(CTCAE) v.5.0, 2017 Available from URL https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_5.0/
  7. Gwak MD, Suh SY. The assessment tools in palliative medicine. Korean J Hosp Palliat Care 12:177-193, 2009 https://doi.org/10.14475/kjhpc.2009.12.4.177
  8. National Statistical Office. Cause of death statistics. 2018 Available from URL http://www.index.go.kr/potal/main/EachDtlPageDetail.do?idx_cd=2770 access date 23.05.2019
  9. National Cancer Information Center Available from:URL https://www.cancer.go.kr/lay1/program/S1T211C215/cancer/view.do?cancer_seq=5237&menu_seq=5255 access date 23.05.2019
  10. Park JW, Jeon HJ, Cho CK, Lee YWOne Case Study of a Non Small Cell Lung Cancer Patient Experiencing Gefitinib Adverse Effects Managed by Traditional Korean Medicine. J of Kor. Traditional Oncology 27(1):9-16, 2012
  11. Kim KS, Case Study: Regression of a Residual Tumor and Prolongation of Overall Survival with Allergen-removed Rhus verniciflua Stokes after Chemoradiotherapy in Locally Advanced Non-small Cell Lung Cancer. J of Int. Korean Med 36(2):200-206, 2015
  12. Jung HJ, Kim JD. The Role of Korean Medicine for Treatment and Management for Lung Cancer. J of Kor. Traditional Oncology 20(1):45-54, 2015 https://doi.org/10.15432/JKTO.2015.20.1.045
  13. FDA Professional Drug Information on Alectinib. Available fromURL https://www.drugs.com/ppa/alectinib.html access date 23.05.2019
  14. Kim JH. A Case of Patient with Recurring Non-Small Cell Lung Carcinoma Treated with Samchilchoongcho-Jung in Conjunction with Afatinib. J of Int. Korean Med 38(1):72-80, 2017 https://doi.org/10.22246/jikm.2017.38.1.72
  15. Park SC, Yoo HS, Park C, Cho CK, Kim GY, Kim WJ. Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt. J of Kor. Traditional Oncology 35(1):121-127, 2009
  16. Park SE, Yoo HS, Jin CY, Hong SH, Lee YW, Kim BW, et al. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris. Food Chem Toxicol. 47(7):1667-1675, 2009 https://doi.org/10.1016/j.fct.2009.04.014
  17. Li CC, Lee YC, Lo HY, Huang YW, Hsiang CY, Ho TY. Antihypertensive Effects of Corn Silk Extract and Its Novel Bioactive Constituent in Spontaneously Hypertensive Rats: The Involvement of Angiotensin-Converting Enzyme Inhibition. Molecules. 24(10):1886, 2019 https://doi.org/10.3390/molecules24101886
  18. Weir MR, Rosenberger C, Fink JC. Pilot study to evaluate a water displacement technique to compare effects of diuretics and ACE inhibitors to alleviate lower extremity edema due to dihydropyridine calcium antagonists. Am J Hypertens 14(9):963-968, 2001 https://doi.org/10.1016/S0895-7061(01)02167-7
  19. Thomas, Rajesh, Lee YC. Causes and management of common benign pleural effusions. Thoracic surgery clinics 23(1):25-42, 2013 https://doi.org/10.1016/j.thorsurg.2012.10.004
  20. Hussain S F, Grayez J, Grigorian A , Green J T. Massive pleural effusion and marked increase of CA-125. Postgraduate medical journal 80(943): 300-301, 2004 https://doi.org/10.1136/pgmj.2003.012377