DOI QR코드

DOI QR Code

A Case Report of Metastatic Leiomyosarcoma Patient Treated with Integrative Cancer Treatment

전이성 평활근육종 환자의 통합 암 치료에 대한 증례보고

  • Song, Si-yeon (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Chang, Hyeok-joon (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Park, So-jung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Jun, Hyeong-joon (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Lee, Yeon-weol (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Cho, Chong-kwan (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Yoo, Hwa-seung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
  • 송시연 (대전대학교 둔산한방병원 동서암센터) ;
  • 장혁준 (대전대학교 둔산한방병원 동서암센터) ;
  • 박소정 (대전대학교 둔산한방병원 동서암센터) ;
  • 전형준 (대전대학교 둔산한방병원 동서암센터) ;
  • 이연월 (대전대학교 둔산한방병원 동서암센터) ;
  • 조종관 (대전대학교 둔산한방병원 동서암센터) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Received : 2019.05.31
  • Accepted : 2019.06.23
  • Published : 2019.06.30

Abstract

Objective: The purpose of this study is to report the effectiveness and possibility of Integrative Cancer Treatment (ICT) on an advanced metastatic leiomyosarcoma patient. Methods: The patient was diagnosed with recurred and advanced metastatic Leiomyosarcoma, suffering from dyspnea, abdominal discomfort, lower limb edema. The patient refused conventional treatment, such as chemotherapy, radiotherapy but was treated with ICT including acupuncture, pharmacopuncture, moxibustion, hypertherapy and herbal medicine for symptom management. The clinical outcomes were measured by NRS (Numeral rating scale). Results: After treatment, dyspnea, abdominal discomfort and lower limb edema was relieved from NRS 6 to 3, 7 to 3 and 7 to 6 respectively. Also, loss of body weight, decrease in abdominal, thigh and calf circumference were improved. During and after treatment, we found neither hepatotoxicity nor nephrotoxicity on laboratory findings. Conclusion: This case study suggests that ICT may improve symptom relief and life quality of leiomyosarcoma patient.

Keywords

HJJJCF_2019_v24n1_11_f0001.png 이미지

Figure 1. Patient’s PET-CT image

HJJJCF_2019_v24n1_11_f0002.png 이미지

Figure 2. Imaging Examinations

HJJJCF_2019_v24n1_11_f0003.png 이미지

Figure 3. Changes in weight, abdominal circumference, thigh circumference, calf circumference, during hospitalization.

References

  1. Cho SH, Lee JH, Choi SR, Baek YH, Yoon HA, Lee CJ, Choi SW, Han J. A case of leiomyosarcoma of the sigmoid colon presenting as intussusception. Korean J Gastrointest Endosc 40:270-274, 2010
  2. Yang J, Du X, Chen K, Ylipaa A, Lazar AJ, Trent J, Lev D, Pollock R, Hao X, Hunt K, Zhang W. Genetic aberrations in soft tissue leiomyosarcoma. Cancer Lett 275:1-8, 2009 https://doi.org/10.1016/j.canlet.2008.06.013
  3. Abu-Rustum NR, Curtin JP, Burt M, Jones WB. Regression of uterine low-grade smooth-muscle tumors metastatic to the lung after oophorectomy. Obstet Gynecol 89(5):850-852, 1997 https://doi.org/10.1016/S0029-7844(97)00033-1
  4. Hardman MP, Roman JJ Burnett AF, Santin AD. Metastatic Uterine Leiomyosarcoma Regression Using an Aromatase Inhibitor. Obstetrics & Gynecology 110(2):518-520, 2007 https://doi.org/10.1097/01.AOG.0000267533.56546.c2
  5. Van der Zee J. Heating the patient: a promising approach? Ann Oncol 13(8):1173-1184, 2002 https://doi.org/10.1093/annonc/mdf280
  6. Iwasa K, Taniguchi K, Noguchi M, Yamashita H, Kitagawa M. Leiomyosarcoma of the colon presenting as acute suppurative peritonitis. Surg Today 27:337-344, 1997 https://doi.org/10.1007/BF00941809
  7. Azar T, Berger DL. Adult intussusception. Ann Surg 1997;226: 134-138. https://doi.org/10.1097/00000658-199708000-00003
  8. Conlon KC, Casper ES, Brennan MF. Primary gastrointestinal sarcomas: analysis of prognostic variables. Ann Surg Oncol 2:26-31, 1995 https://doi.org/10.1007/BF02303698
  9. Warkel RL, Stewart JB, Temple AJ. Leiomyosarcoma of the colon: report of a case and analysis of the relationship of histology to prognosis. Dis Colon Rectum 18:501-506, 1975 https://doi.org/10.1007/BF02587219
  10. O'Sullivan PJ, Harris AC, Munk PL. Radiological imaging features of non-uterine leiomyosarcoma. Br J Radiol 81:73-81, 2008 https://doi.org/10.1259/bjr/18595145
  11. Stair JM, Stevenson DR , Schaefer RF, Lang NP. Leiomyosarcoma of the rectum: Report of three cases. J Surg Oncol 24:180-183, 1983 https://doi.org/10.1002/jso.2930240307
  12. Anderson PA, Dockerty MB, Buie LA. Myomatous tumors of the rectum(leiomyosarcoma and leiomyoma). Surgery 28:642, 1950
  13. Shiu MH, Farr GH, Papachristou DN, Hajdu SI. Myosarcomas of the stomach: natural history, prognostic factors and management. Cancer 49:177-187, 1982 https://doi.org/10.1002/1097-0142(19820101)49:1<177::AID-CNCR2820490136>3.0.CO;2-K
  14. Ng EH, Pollock RE, Romsdahl MM. Prognostic implications of patterns of failure for gastrointestinal leiomyosarcomas. Cancer 69:1334-1341, 1992 https://doi.org/10.1002/1097-0142(19920315)69:6<1334::AID-CNCR2820690606>3.0.CO;2-S
  15. Lee SH, Choi WC, Kim KS, Park JW, Lee SH, Yoon SW. Shrinkage of gastric cancer in an elderly patient who received Rhus verniciflua Stokes extract. The Journal of Alternative and Complementary Medicine 16(4):497-500, 2010 https://doi.org/10.1089/acm.2008.0237
  16. Song AN, Ahn JH, Kim KS, Jung HS, Lee SK, Choi WC. Long Term Survival of a Patient with Advanced Non-Small Cell Lung Cancer Treated with Allergen Removed Rhus verniciflua Stokes Extract; a Case Report. Journal of Korean traditional oncology 17(1):39-43, 2012 https://doi.org/10.15432/JKTO.2012.17.1.039
  17. Son CK, Han SS. A Study on the Immune Modulation and Hepato-protection of Gamichunggantang. Journal of Korean Medicine 23(2): 28-38, 2002
  18. Cho JH, Lee YY, Seo SH, Yoo HS, Choi WJ, Lee YW, Son CK, Cho CK. A Clinical Report about 57 Patients with Chronic Liver Disease. Journal of Korean Medicine 21(4):112-21, 2000