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Effect of Aerobic Exercise Program Participation on the Dementia-related Factor and Cognitive Function in Elderly Women with Dementia

유산소운동프로그램 참여가 경증치매 여성 노인의 치매관련 인자 및 인지기능에 미치는 영향

  • 정진협 (한양대학교 생활스포츠학과)
  • Received : 2019.03.22
  • Accepted : 2019.06.20
  • Published : 2019.06.28

Abstract

This study aimed to investigate the effects of participating in an aerobic exercise program three days a week and 50 minutes a day on dementia related factors and cognitive function in elderly women with mild dementia. For this, among 17 elderly women aged 65 and above, 10 elderly women were randomly assigned to the experimental group and 7 elderly wonmen to the control group. As a result of comparative analysis, conclusions were drawn as follows: There was a significant difference (p<.05) in the DHEA-s change between the two groups according to whether or not the aerobic exercise program was performed. Changes in cognitive function did not show any significant difference in the interaction effects of group, period, period${\times}$group. These results suggest that the aerobic exercise program did not show statistically significant effects on the dementia related factors and cognitive function changes of the elderly women with mild dementia. The reason for this is that the followings should be analyzed in more detail, but the lack of control on the daily life (diet) of the study subjects, which was considered as a limitation in this study, seems to be the biggest cause. Based on the results of this study, we hope that this study will be used as a basic data for improving the quality of dementia.

본 연구의 대상은 만 65세 이상 경증치매 여성 노인이며, 실험군 10명, 통제군 7명으로 1주 3회 1일 50분의 유산소운동프로그램 참여가 연구대상자의 치매관련인자 및 인지기능에 미치는 영향을 알아보기 위하여 분석한 결과는 아래와 같다. 운동프로그램 실시 유무에 따른 집단 간 DHEA-s의 변화는 두 집단간 유의한 차이(p<.05)가 나타났지만, 시기${\times}$집단의 상호작용 효과에서는 유의한 차이가 나타나지 않았다. 인지기능은 그룹, 시기, 시기${\times}$집단의 상호작용 효과 모두 통계적으로 유의한 차이가 나타나지 않았다. 이상의 내용을 종합해 보면 본 연구에서 활용된 운동프로그램은 경증치매 여성 노인의 치매관련 인자 및 인지기능 변화에 의미있는 효과를 나타내지 못했음을 알 수 있다. 이와 같은 결과는 후속연구를 통해 자세히 다시 알아볼 필요성이 있지만, 본 연구의 제한점이었던 연구대상자들의 일상생활(식생활)에 대한 통제의 부재가 가장 큰 원인일 것으로 사료된다. 이에 더 나아가 본 연구의 결과를 토대로 다양한 계층에서 치매관련 인자 및 인지기능의 질적 개선을 위한 연구의 기초 자료로 활용되기를 기대한다.

Keywords

Table 1. The Physical Characteristic of Subject

OHHGBW_2019_v10n6_227_t0001.png 이미지

Table 2. Exercise Program

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Table 3. Two-way repeated ANOVA about The change of DHEA-s

OHHGBW_2019_v10n6_227_t0003.png 이미지

Table 4. The result of paired t-test on the Pre and Post of DHEA-s

OHHGBW_2019_v10n6_227_t0004.png 이미지

Table 5. The result of paired t-test on the Pre and Post of DHEA-s

OHHGBW_2019_v10n6_227_t0005.png 이미지

Table 6. Two-way repeated ANOVA about The change of MMSE-K

OHHGBW_2019_v10n6_227_t0006.png 이미지

Table 7. The result of paired t-test on the Pre and Post of MMSE-K

OHHGBW_2019_v10n6_227_t0007.png 이미지

Table 8. The result of paired t-test on the Pre and Post of MMSE-K

OHHGBW_2019_v10n6_227_t0008.png 이미지

References

  1. McDowell, I. (2001). Alzheimer's disease Insight from epidemiology. Aging(Milano), 13(3), 143-162.
  2. Prince, J. A., Zetterberg, H., Andreasen, N., Marcusson, J. & Blennow, K.(2004). APOE ${\varepsilon}4$ allele is associated with reduced cerebrospinal fluid levels of A${\beta}4$2. Neurology, 62(11), 2116-2118. https://doi.org/10.1212/01.WNL.0000128088.08695.05
  3. Thomas, G, Frenoy, N, Legrain, S, Sebag-Lanoe, R, Baulieu, E. E & Debuire B.(1994). Serum dehydroepiandrosterone sulfate levels as an individual marker. The Journal of clinical endocrinology and metabolism, 79, 273-276.
  4. M. Kalimi & W. Regelson. (1990). The biologic role of dehydroepiandrosterone(DHEA), Walter de Gruyter, Berlin, New York, Journal of the American Medical Association, 264(8), 1026-1027. https://doi.org/10.1001/jama.1990.03450080112042
  5. Orentrich, N., Brind, J. L., Vogelman, J. H., Andres, R. & Baldwin, H.(1992). Long term logitudinal measument of plasma dehydroepiandrosterone sulfate in normal me. The Journal of clinical endocrinology and metabolism, 75(4), 1002-1004. https://doi.org/10.1210/jc.75.4.1002
  6. C. K. Yoo. (2004). The effects of combined exercise on health related fitness B-amyloid and DHEAs concentration in elderly women. Dept. of Physical Education Graduate School, Dong-A University.
  7. Bergerone, J., Couillard, C., Despres, J. P., Gagnon, J., Leon, A. S., Rao, D. C., Skinner, J. S., Willmore, J. H. & Bouchard, C. (2001). Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men; result from the HERITAGE Family Study. Atherosclerosis, 159(2), 399-406. https://doi.org/10.1016/S0021-9150(01)00515-9
  8. Fahlman, M. M., Boardley, D. L., Charles, P. F. & Michael G. (2002). Effects of endurance training and resistance training on plasma lipoprotein profiles in elderly women. The journals of Gerontology, 57(2), 54-60.
  9. Casson, P. R., Faquin, L. C. & Stenz, F. B. (1995). Replacement of dehydroepiandrosterone enhances T-lymphocyte insulin binding in postmenopausal women. Fertility and Sterility, 63(5), 1027-1031. https://doi.org/10.1016/S0015-0282(16)57542-6
  10. Mottl, R., & Cerman, J. A.(2004). Relationship between dehydroepiandrosterone sulphate and insulin resistance in obese men and women. Vnitrni lekarstvi, 50(12), 923-929.
  11. Labrie, F., Diamond, P., Cusan, L., Gomez, J. L., Belanger, A. & Candas, B.(1997). Effect of 12-month dehydroepiandtrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. The Journal of clinical endocrinology and metabolism, 82(10), 3498-3505. https://doi.org/10.1210/jcem.82.10.4306
  12. Thomas, G, Frenoy, N, Legrain, S, Sebag-Lanoe, R, Baulieu, E. E. & Debuire B.(1994). Serum dehydroepiandrosterone sulfate levels as an individual marker. The Journal of clinical endocrinology and metabolism, 79, 273-276.
  13. Laurin, D., Verreault, R., Lindsay, J., MacPherson, K. & Rockwood, K. (2001). Physical activity and risk of cognitive impairment and dementia in elderly persons. Archives Neurology, 58(3), 498-504. https://doi.org/10.1001/archneur.58.3.498
  14. Stoedefalke, K. G. (1985). Motivation and sustaining the older adult in an exercise program. Aspen System Corporation, 1(1), 78-83.
  15. A. R. Joo & S. H. Park. (2004). The Relationship between Cognitive Function and Depression in Elderly People in Rural Areas. J. of Korean Gerontological Nursing, 6(1), 27-37.
  16. J. H. Shon & H. S. Yoo. (2010). Effects of Chronic Combined Exercise on Cognitive Function and Depression in Elderly Women. Korean Society of Sport Psychology, 21(4), 183-195.
  17. Sumic, A., Michael, Y. L., Carlson, N. E., Howieson, D. B. & Kaye, J. A. (2007). Physical activity and the risk of dementia in oldest women. Journal of Aging and Health, 19(2), 242-259. https://doi.org/10.1177/0898264307299299
  18. Larson, E. B., Wang, L., Bowen, J. D., McCormick, W. C. Teri, L., Crane, P. & Kukull, W.(2006). Exercise is associated with reduced risk for incident dementia among persons 65 years of age or older. Annals of Internal Medicine, 144, 74-81.
  19. Borg. (1920). Perceived exertion as an indicator of somatic stress. Scand J. Rehabil. Med., 2, 92-98.
  20. ACSM(2003). ACSM's Resource Mannual for Guideline for Exercise Testing and Prescription.
  21. Orentrich, N., Brind, J. L., Vogelman, J. H., Andres, R. & Baldwin, H.(1992). Long term logitudinal measument of plasma dehydroepiandrosterone sulfate in normal me. The Journal of clinical endocrinology and metabolism, 75(4), 1002-1004. https://doi.org/10.1210/jc.75.4.1002
  22. Gray, A., Feldman, H.A., McKinlay, J.B. & Longcope, C.(1991). Age, disease and cognitive function in community-dwelling elderly women, Diabets Care, 24(6), 1060-1065.
  23. Frisoni, G. B., Padovani, A. & Wahlund, L. O. (2004). The predementia diagnosis of Alzheimer's disease. Alzheimer's Disease & Associated Disorders, 18(2), 51-53 https://doi.org/10.1097/01.wad.0000126613.05674.0c
  24. Y. C. Kwon. (2004). The effects of combined exercise on health related fitness B-amyloid and DHEAs concentration in elderly women. Dept. of Physical Education Graduate School, Dong-A University..
  25. Barrett C, Elizabeth, & Goodman G., Deborah. (1995). The epidemiology of DHEAS and cardiovascular disease. Annals of the New York Academy of sciences, 774(1), 259-270. https://doi.org/10.1111/j.1749-6632.1995.tb17386.x-i1
  26. Bergerone, J., Couillard, C., Despres, J. P., Gagnon, J., Leon, A. S., Rao, D. C., Skinner, J. S., Willmore, J. H. & Bouchard, C. (2001). Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men; result from the HERITAGE Family Study. Atherosclerosis, 159(2), 399-406. https://doi.org/10.1016/S0021-9150(01)00515-9
  27. Burgener S. C., Buettner L., Coen Buckwalter K., Beattie E., Bossen A. L., Fick D. M., Fitzsimmons S. & Kolanowski A. (2009). Evidence supporting nutritional interventions for persons in early-stage Alzheimer's disease. J Nutr Health Aging. 12, 18-21. https://doi.org/10.1007/BF02982159
  28. Yaffe, K., Barnes, D., Nevitt, M., Lui, L. Y. & Covinsky, K. (2001). A prospective study of physical activity and cognitive decline in elderly women: women who walk. Archives of internal medicine, 161(14), 1703-1708. https://doi.org/10.1001/archinte.161.14.1703
  29. Rogers, R. L., Meyer, J. S. & Mortel, K. F. J. (1990). After reaching retirement age physical activity sustains cerebral perfusion and cognition. Am. Geriatr. Soc., 38(2), 123-128. https://doi.org/10.1111/j.1532-5415.1990.tb03472.x