Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer

  • Ko, Je Yeong (Department of Life Systems, Sookmyung Women's University) ;
  • Lee, Eun Ji (Department of Life Systems, Sookmyung Women's University) ;
  • Park, Jong Hoon (Department of Life Systems, Sookmyung Women's University)
  • Received : 2019.03.29
  • Accepted : 2019.04.05
  • Published : 2019.07.01
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Abstract

Primary cilia and autophagy are two distinct nutrient-sensing machineries required for maintaining intracellular energy homeostasis, either via signal transduction or recycling of macromolecules from cargo breakdown, respectively. Potential correlations between primary cilia and autophagy have been recently suggested and their relationship may increase our understanding of the pathogenesis of human diseases, including ciliopathies and cancer. In this review, we cover the current issues concerning the bidirectional interaction between primary cilia and autophagy and discuss its role in cancer with cilia defect.

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References

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