Journal of information and communication convergence engineering

The Korea Institute of Information and Commucation Engineering (한국정보통신학회)
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Graphene and Carbon Quantum Dots-based Biosensors for Use with Biomaterials

  • Lee, Cheolho (Department of Chemical and Biological Engineering, Seokyeong University) ;
  • Hong, Sungyeap (Department of Chemical and Biological Engineering, Seokyeong University)
  • Received : 2018.07.04
  • Accepted : 2018.12.06
  • Published : 2019.03.31
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Abstract

Biosensors, which are analysis devices used to convert biological reactions into electric signals, are made up of a receptor component and a signal transduction part. Graphene quantum dots (GQDs) and carbon quantum dots (CQDs) are new types of carbon nanoparticles that have drawn a significant amount of attention in nanoparticle research. The unique features exhibited by GQDs and CQDs are their excellent fluorescence, biocompatibility, and low cytotoxicity. As a result of these features, carbon nanomaterials have been extensively studied in bioengineering, including biosensing and bioimaging. It is extremely important to find biomaterials that participate in biological processes. Biomaterials have been studied in the development of fluorescence-based detection methods. This review provides an overview of recent advances and new trends in the area of biosensors based on GQDs and CQDs as biosensor platforms for the detection of biomaterials using fluorescence. The sensing methods are classified based on the types of biomaterials, including nucleic acids, vitamins, amino acids, and glucose.

Keywords

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Fig. 2. Schematic illustration of the fluorescence detection of biothiols based on NCQDs (reproduced from [48]).

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Fig. 3. Schematic illustration of the process used for AA recognition(reproduced from [66]).

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Fig. 4. Schematic of fluorometric and colorimetric assay for glucose detection based on Au@Ag NPs and C-dots (reproduced from [76]).

E1ICAW_2019_v17n1_49_f0004.png 이미지

Fig. 1. (A) Synthesis of P-CDs and (B) the quenching of fluorophore-labeled ssDNA using P-CDs while retaining their stable fluorescence intensity, enabling a ratiometric analytical method for Gardnerella vaginalis DNA with the target sequence circulating under the assistance of Exo III (reproduced from [35]).

Table 1. Comparison of reported techniques for the detection of DNA and amino acids

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Table 2. Comparison of reported techniques for the detection of glucose and pyrophosphate ions

E1ICAW_2019_v17n1_49_t0002.png 이미지

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