Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Genome-wide association study on immune-response for improving healthiness in Holstein dairy cattle

Holstein 젖소의 호흡기 질병 백신에 대한 면역반응성과 전장 유전체 연관 분석 연구

  • Ha, Seungmin (National Institute of Animal Science, Rural Development Administration) ;
  • Lee, Donghui (Department of Animal Science & Technology, Sunchon National University) ;
  • Lee, Sangmyeong (Division of Biotechnology, Chonbuk National University) ;
  • Chae, Jungil (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University) ;
  • Seo, Kangseok (Department of Animal Science & Technology, Sunchon National University)
  • 하승민 (농촌진흥청 국립축산과학원) ;
  • 이동희 (순천대학교 동물자원과학과) ;
  • 이상명 (전북대학교 생명공학부) ;
  • 채정일 (전북대학교 치과대학) ;
  • 서강석 (순천대학교 동물자원과학과)
  • Received : 2019.11.06
  • Accepted : 2019.12.18
  • Published : 2019.12.30
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Abstract

To detect Single nucleotide polymorphisms (SNP) markers associated with Bovine viral diarrhea virus (BVDV) and Bovine respiratory syncytial virus (BRSV) S/P ratio in Korean Holstein dairy cattle, Genome-wide association study (GWAS) was performed using Illumina BovineSNP50 Beadchip. The number of phenotype data and genotype data were 107, and 294. respectively. Phenotype data were collected for four periods (0 week, 1 week, 4 week, 24 week) after having vaccinated (0 week no vaccinated period). A total of 36,257 SNPs was remained after quality control had been done by PLINK. The result of GWAS showed 6 SNP markers (BTB-01704243, BTB-01594395, ARS-BFGL-NGS-118070, ARS-BFGL-NGS-111365, BTA-65410-no-rs, Hapmap38331-BTA-61256) under BVDV and 4 SNP markers (ARS-BFGL-NGS-109861, Hapmap53701-rs29017064, ARS-BFGL-NGS-71055, BTA-11232-no-rs) under BRSV. And also, 10 candidate genes found through 10 SNP markers (TBX18, CEP162, PAFAH1B1, METTL16, BRCA1, RND2, POLK, ENSBTAG00000051724, ADAM18, NRG3).

Keywords

References

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