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http://dx.doi.org/10.7853/kjvs.2019.42.4.217

Genome-wide association study on immune-response for improving healthiness in Holstein dairy cattle  

Ha, Seungmin (National Institute of Animal Science, Rural Development Administration)
Lee, Donghui (Department of Animal Science & Technology, Sunchon National University)
Lee, Sangmyeong (Division of Biotechnology, Chonbuk National University)
Chae, Jungil (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University)
Seo, Kangseok (Department of Animal Science & Technology, Sunchon National University)
Publication Information
Korean Journal of Veterinary Service / v.42, no.4, 2019 , pp. 217-225 More about this Journal
Abstract
To detect Single nucleotide polymorphisms (SNP) markers associated with Bovine viral diarrhea virus (BVDV) and Bovine respiratory syncytial virus (BRSV) S/P ratio in Korean Holstein dairy cattle, Genome-wide association study (GWAS) was performed using Illumina BovineSNP50 Beadchip. The number of phenotype data and genotype data were 107, and 294. respectively. Phenotype data were collected for four periods (0 week, 1 week, 4 week, 24 week) after having vaccinated (0 week no vaccinated period). A total of 36,257 SNPs was remained after quality control had been done by PLINK. The result of GWAS showed 6 SNP markers (BTB-01704243, BTB-01594395, ARS-BFGL-NGS-118070, ARS-BFGL-NGS-111365, BTA-65410-no-rs, Hapmap38331-BTA-61256) under BVDV and 4 SNP markers (ARS-BFGL-NGS-109861, Hapmap53701-rs29017064, ARS-BFGL-NGS-71055, BTA-11232-no-rs) under BRSV. And also, 10 candidate genes found through 10 SNP markers (TBX18, CEP162, PAFAH1B1, METTL16, BRCA1, RND2, POLK, ENSBTAG00000051724, ADAM18, NRG3).
Keywords
BVDV; BRSV; SNP; GWAS; Holstein;
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