한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제36권4호
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  • Pages.1198-1207
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  • 2019
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  • 1225-9098(pISSN)
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  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
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비만모델 랫드에서 지장김치의 혈액 지질대사, 항비만 효능 및 메카니즘

Biochemical mechanism of Jijang-Kimch on anti-obesity effect and blood lipid metabolism in obesity model rats

  • 신종서 (강원대학교 동물생명과학대학) ;
  • 엄경환 (강원대학교 동물생명과학대학) ;
  • 최윤서 (강원대학교 동물생명과학대학) ;
  • 이혜선 (강원대학교 동물생명과학대학) ;
  • 박희진 (강원대학교 동물생명과학대학) ;
  • 박병성 (강원대학교 동물생명과학대학)
  • Shin, J.S. (College of Animal Life Sciences, Kangwon National University) ;
  • Um, K.H. (College of Animal Life Sciences, Kangwon National University) ;
  • Choi, Y.S. (College of Animal Life Sciences, Kangwon National University) ;
  • Lee, H.S. (College of Animal Life Sciences, Kangwon National University) ;
  • Park, H.J. (College of Animal Life Sciences, Kangwon National University) ;
  • Park, B.S. (College of Animal Life Sciences, Kangwon National University)
  • 투고 : 2019.12.04
  • 심사 : 2019.12.26
  • 발행 : 2019.12.30
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초록

고지방식이에 의해 유도한 비만모델동물에서 지장김치의 혈액 중 유해 지질 감소, 항비만 효능 및 그 작용 메카니즘을 조사하였다. 4개의 처리구는 CD(일반식이를 섭취한 정상 대조구, chow diet as normal control), HFD(고지방식이를 섭취한 비만 대조구, high fat diet as obesity), HFDCK(고지방식이+일반김치 추출물 투여구), HFDJK(고지방식이+지장김치 추출물 투여구)로 구분하여 김치추출물을 28일 동안 경구투여 하였다. 체중, 간 및 지방조직 무게는 비만모델동물에서 HFDJK가 HFDCK에 비해서 낮았다(p<0.05). 혈액 중성지방, 총콜레스테롤, LDL-C, 혈당은 HFD와 비교할 때 CD, HFDJK, HFDCK의 순서대로 낮았으며 HFDJK는 HFDCK에 비해 낮았다(p<0.05). 간 및 지방세포의 크기는 HFD, HFDCK, HFDJK의 순서대로 증가하였으며 HFDJK는 HFDCK에 비해서 크게 낮았다(p<0.05). 결과는 비만모델동물에서 지장김치의 섭취가 일반김치에 비해서 혈액 지질과 혈당을 낮추고 지방세포의 크기를 줄여줌으로써 항비만 효능을 갖는다는 점을 나타낸다.

This study investigated action mechanism and biological effect of Jijang-kimch, including its anti-obesity effect and blood lipid-decreasing effect in a high-fat diet-induced obese model animals. There were four treatment groups: CD (chow diet as normal control), HFD (high fat diet as obesity control), HFDCK (HFD plus commercial kimchi extracts), and HFDJK (HFD plus Jijang-kimchi extract). Kimchi extracts were orally administered for 28 days. Body weight, liver, and adipose tissue weight declined in HFDJK compared to those in HFDCK(p<0.05). Blood triglyceride, total cholesterol, low density lipoprotein-cholesterol (LDL-C), and glucose level decreased in CD, HFDJK, and HFDCK compared to those in HFD(p<0.05). Those in HFDJK were lower than those in HFDCK(p<0.05). Sizes of liver and adipose cells increased in HFD, HFDCK, and HFDJ that those in CD(p<0.05). Those in HFDJK were greatly decreased than those in HFDCK(p<0.05). These results indicate that ingestion of Jijang-kimchi in obese model animals has anti-obesity effect by lowering blood lipid and glucose levels and decreasing adipocyte size compared to that of commercial-kimchi.

키워드

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