Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Pathophysiological Role of S-Nitrosylation and Transnitrosylation Depending on S-Nitrosoglutathione Levels Regulated by S-Nitrosoglutathione Reductase

  • Choi, Min Sik (Lab of Pharmacology, College of Pharmacy, Dongduk Women's University)
  • Received : 2018.09.18
  • Accepted : 2018.10.06
  • Published : 2018.11.01
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Abstract

Nitric oxide (NO) mediates various physiological and pathological processes, including cell proliferation, differentiation, and inflammation. Protein S-nitrosylation (SNO), a NO-mediated reversible protein modification, leads to changes in the activity and function of target proteins. Recent findings on protein-protein transnitrosylation reactions (transfer of an NO group from one protein to another) have unveiled the mechanism of NO modulation of specific signaling pathways. The intracellular level of S-nitrosoglutathione (GSNO), a major reactive NO species, is controlled by GSNO reductase (GSNOR), a major regulator of NO/SNO signaling. Increasing number of GSNOR-related studies have shown the important role that denitrosylation plays in cellular NO/SNO homeostasis and human pathophysiology. This review introduces recent evidence of GSNO-mediated NO/SNO signaling depending on GSNOR expression or activity. In addition, the applicability of GSNOR as a target for drug therapy will be discussed in this review.

Keywords

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  2. Can Serum Nitrosoproteome Predict Longevity of Aged Women? vol.21, pp.23, 2020, https://doi.org/10.3390/ijms21239009
  3. Post-Translational Modifications of Circulating Alpha-1-Antitrypsin Protein vol.21, pp.23, 2018, https://doi.org/10.3390/ijms21239187
  4. Glutathione in Protein Redox Modulation through S-Glutathionylation and S-Nitrosylation vol.26, pp.2, 2021, https://doi.org/10.3390/molecules26020435
  5. S-nitrosothiols signaling in cystic fibrosis airways vol.46, pp.4, 2018, https://doi.org/10.1007/s12038-021-00223-w
  6. Characterizing the effect of S-nitrosoglutathione on Saccharomyces cerevisiae: Upregulation of alcohol dehydrogenase and inactivation of aconitase vol.113, pp.None, 2018, https://doi.org/10.1016/j.procbio.2021.12.011