Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Sex Differences in Cardiovascular Risk Factors for Dementia

  • Kim, Mi-Young (College of Pharmacy, Ajou University) ;
  • Kim, Kyeongjin (College of Pharmacy, Ajou University) ;
  • Hong, Chang Hyung (Department of Psychiatry, Ajou University School of Medicine) ;
  • Lee, Sang Yoon (Department of Biomedical Sciences, Chronic Inflammatory Disease Research Center, Ajou University School of Medicine) ;
  • Jung, Yi-Sook (College of Pharmacy, Ajou University)
  • Received : 2018.08.14
  • Accepted : 2018.10.06
  • Published : 2018.11.01
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Abstract

Dementia, characterized by a progressive cognitive decline and a cumulative inability to behave independently, is highly associated with other diseases. Various cardiovascular disorders, such as coronary artery disease and atrial fibrillation, are well-known risk factors for dementia. Currently, increasing evidence suggests that sex factors may play an important role in the pathogenesis of diseases, including cardiovascular disease and dementia. Recent studies show that nearly two-thirds of patients diagnosed with Alzheimer's disease are women; however, the incidence difference between men and women remains vague. Therefore, studies are needed to investigate sex-specific differences, which can help understand the pathophysiology of dementia and identify potential therapeutic targets for both sexes. In the present review, we summarize sex differences in the prevalence and incidence of dementia by subtypes. This review also describes sex differences in the risk factors of dementia and examines the impact of risk factors on the incidence of dementia in both sexes.

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References

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  2. Physical function parameters that predict the onset of mild cognitive impairment one year later in community-dwelling elderly women : A propensity-score matched analysis vol.10, pp.3, 2018, https://doi.org/10.9759/hppt.10.117
  3. Alzheimer's Disease and Cardiovascular Disease: A Particular Association vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/2617970
  4. Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial vol.17, pp.7, 2018, https://doi.org/10.1002/alz.12279
  5. Decomposition of gender differences in cognitive functioning: National Survey of the Japanese elderly vol.21, pp.1, 2018, https://doi.org/10.1186/s12877-020-01990-1
  6. Long-term ozone exposure and cognitive impairment among Chinese older adults: A cohort study vol.160, pp.None, 2018, https://doi.org/10.1016/j.envint.2021.107072