DOI QR코드

DOI QR Code

Surgery for Advanced Nodal Metastasis in Thyroid Cancer

갑상선암에서 진행된 림프절 전이에 대한 수술적 치료

  • Park, Min Woo (Department of Otorhinolaryngology-Head and Neck Surgery, Kangdong Sacred Heart Hospital, Ilsong Memorial Head and Neck Thyroid Cancer Hospital, Hallym University College of Medicine) ;
  • Rho, Young Soo (Department of Otorhinolaryngology-Head and Neck Surgery, Kangdong Sacred Heart Hospital, Ilsong Memorial Head and Neck Thyroid Cancer Hospital, Hallym University College of Medicine)
  • 박민우 (한림대학교 의과대학 강동성심병원 이비인후과학교실) ;
  • 노영수 (한림대학교 의과대학 강동성심병원 이비인후과학교실)
  • Received : 2018.09.20
  • Accepted : 2018.11.22
  • Published : 2018.11.30

Abstract

Metastases to regional cervical lymph nodes occur frequently in patients with thyroid cancer. The appropriate management of regional lymph node is important to achieve good disease control and to classify risk stratification for adjuvant radioactive iodine. However, there are some occasions that neck dissection is difficult and embarrassing in thyroid cancer. Especially, extensive or unusual nodal metastases bring challenges and makes neck dissection more difficult. Carotid artery management is one of the most difficult procedure in neck dissection. The management of patients who have persistent or recurrent cervical metastasis involving the carotid artery has been controversial and treatment dilemma to the surgeon. Metastasis of well differentiated thyroid cancer to the retropharyngeal lymph nodes is rare but occasionally encountered. The complete surgical excision is usually recommended for retropharyngeal lymph node metastasis of well differentiated thyroid cancer. An extensive mediastinal dissection in advanced differentiated thyroid carcinoma is occasionally required. This paper will review recent reports of management of advanced nodal metastasis of thyroid cancer and share the author's personal experience.

Keywords

References

  1. Gambardella C, Tartaglia E, Nunziata A, Izzo G, Siciliano G, Cavallo F, et al. Clinical significance of prophylactic central compartment neck dissection in the treatment of clinically node-negative papillary thyroid cancer patients. World J Surg Oncol 2016;14(1):247. https://doi.org/10.1186/s12957-016-1003-5
  2. Conzo G, Tartaglia E, Avenia N, Calo PG, de Bellis A, Esposito K, et al. Role of prophylactic central compartment lymph node dissection in clinically N0 differentiated thyroid cancer patients: analysis of risk factors and review of modern trends. World J Surg Oncol 2016;14:149. https://doi.org/10.1186/s12957-016-0879-4
  3. Liang J, Li Z, Fang F, Yu T, Li S. Is prophylactic central neck dissection necessary for cN0 differentiated thyroid cancer patients at initial treatment? A meta-analysis of the literature. Acta Otorhinolaryngol Ital 2017;37(1):1-8.
  4. Hughes DT, Rosen JE, Evans DB, Grubbs E, Wang TS, Solorzano CC. Prophylactic central compartment neck dissection in papillary thyroid cancer and effect on locoregional recurrence. Ann Surg Oncol 2018;25(9):2526-34. https://doi.org/10.1245/s10434-018-6528-0
  5. Goyal N, Pakdaman M, Kamani D, Caragacianu D, Goldenberg D, Randolph GW. Mapping the distribution of nodal metastases in papillary thyroid carcinoma: Where exactly are the nodes? Laryngoscope 2017;127(8):1959-64. https://doi.org/10.1002/lary.26495
  6. Lodder WL, Lange CA, Teertstra HJ, Pameijer FA, van den Brekel MW, Balm AJ. Value of MR and CT imaging for assessment of internal carotid artery encasement in head and neck squamous cell carcinoma. Int J Surg Oncol 2013;2013:968758.
  7. Mourad M, Saman M, Stroman D, Lee T, Ducic Y. Carotid artery sacrifice and reconstruction in the setting of advanced head and neck cancer. Otolaryngol Head Neck Surg 2015;153(2):225-30. https://doi.org/10.1177/0194599815586719
  8. Back LJJ, Aro K, Tapiovaara L, Vikatmaa P, de Bree R, Fernandez-Alvarez V, et al. Sacrifice and extracranial reconstruction of the common or internal carotid artery in advanced head and neck carcinoma: review and meta-analysis. Head Neck 2018;40(6):1305-20. https://doi.org/10.1002/hed.25093
  9. Katsuno S, Takemae T, Ishiyama T, Usami SI. Is carotid reconstruction for advanced cancer in the neck a safe procedure? Otolaryngol Head Neck Surg 2001;124(2):222-4. https://doi.org/10.1067/mhn.2001.112482
  10. Ozer E, Agrawal A, Ozer HG, Schuller DE. The impact of surgery in the management of the head and neck carcinoma involving the carotid artery. Laryngoscope 2008;118(10):1771-4. https://doi.org/10.1097/MLG.0b013e31817f6dc7
  11. Miao B, Lu Y, Pan X, Liu D. Carotid artery resection and reconstruction with expanded polytetrafluoroethylene for head and neck cancer. Laryngoscope 2008;118(12):2135-8. https://doi.org/10.1097/MLG.0b013e318182a50e
  12. Otsuki N, Nishikawa T, Iwae S, Saito M, Mohri M, Nibu K. Retropharyngeal node metastasis from papillary thyroid carcinoma. Head Neck 2007;29(5):508-11. https://doi.org/10.1002/hed.20536
  13. Hartl DM, Leboulleux S, Velayoudom-Cephise FL, Mirghani H, Deandreis D, Schlumberger M. Management of retropharyngeal node metastases from thyroid carcinoma. World J Surg 2015;39(5):1274-81. https://doi.org/10.1007/s00268-015-2947-2
  14. Reddy A, Verma AK, Mayilvaganan S. Management of retropharyngeal node metastases from thyroid carcinoma. World J Surg 2016;40(2):488. https://doi.org/10.1007/s00268-015-3171-9
  15. Togashi T, Sugitani I, Toda K, Kawabata K, Takahashi S. Surgical management of retropharyngeal nodes metastases from papillary thyroid carcinoma. World J Surg 2014;38(11):2831-7. https://doi.org/10.1007/s00268-014-2707-8
  16. American Thyroid Association Surgery Working Group, American Association of Endocrine Surgeons, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society, Carty SE, Cooper DS, et al. Consensus statement on the terminology and classification of central neck dissection for thyroid cancer. Thyroid 2009;19(11):1153-8. https://doi.org/10.1089/thy.2009.0159
  17. Machens A, Dralle H. Prediction of mediastinal lymph node metastasis in papillary thyroid cancer. Ann Surg Oncol 2009;16(1):171-6. https://doi.org/10.1245/s10434-008-0201-y
  18. Ito Y, Miyauchi A. Lateral and mediastinal lymph node dissection in differentiated thyroid carcinoma: indications, benefits, and risks. World J Surg 2007;31(5):905-15. https://doi.org/10.1007/s00268-006-0722-0
  19. Kikumori T, Imai T. Insignificance of prophylactic upper mediastinal lymph node dissection by sternotomy for papillary thyroid carcinoma. Endocr J 2011;58(12):1093-8. https://doi.org/10.1507/endocrj.EJ11-0226
  20. Clayman GL, Shellenberger TD, Ginsberg LE, Edeiken BS, El-Naggar AK, Sellin RV, et al. Approach and safety of comprehensive central compartment dissection in patients with recurrent papillary thyroid carcinoma. Head Neck 2009;31(9):1152-63. https://doi.org/10.1002/hed.21079
  21. Liu J, Wang X, Liu S, Liu X, Tang P, Xu Z. Superior mediastinal dissection for papillary thyroid carcinoma: approaches and outcomes. ORL J Otorhinolaryngol Relat Spec 2013;75(4):228-39. https://doi.org/10.1159/000353549
  22. Wang LY, Versnick MA, Gill AJ, Lee JC, Sidhu SB, Sywak MS, et al. Level VII is an important component of central neck dissection for papillary thyroid cancer. Ann Surg Oncol 2013;20(7):2261-5. https://doi.org/10.1245/s10434-012-2833-1