Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Diagnostic and prognostic value of proadrenomedullin in neonatal sepsis

  • 투고 : 2017.11.25
  • 심사 : 2018.03.26
  • 발행 : 2018.05.15
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초록

Purpose: Sepsis is a major cause of neonatal morbidity and mortality. Early diagnosis is a major problem because of the lack of specific clinical signs. Therefore, a reliable diagnostic marker is needed to guide the use of antimicrobial agents. The objective of our study was to assess the value of proadrenomedullin (pro-ADM) in establishing the diagnosis and evaluating the prognosis of neonatal sepsis. Methods: This study enrolled 60 newborn infants with sepsis proven with positive blood cultures and 30 healthy neonates. Complete blood count, C-reactive protein levels, and pro-ADM levels were obtained from all neonates. Results: The pro-ADM levels were significantly higher ($14.39{\pm}0.75nmol/L$) in the sepsis group than in the control group ($3.12{\pm}0.23nmol/L$). The optimal cutoff value for pro-ADM was 4.3 nmol/L, with a sensitivity of 93.3% and a specificity of 86.7%. The pro-ADM levels were also higher in nonsurvivors (P=0.001). Conclusion: Pro-ADM can be used as a reliable biomarker for neonatal sepsis. High pro-ADM levels were associated with mortality and could be an early indicator of disease outcome.

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참고문헌

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피인용 문헌

  1. The Role of Pro-Adrenomedullin as a Marker of Severe Bacterial Infection in Children: A Review vol.2, pp.3, 2018, https://doi.org/10.3390/reports2030017
  2. Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing vol.26, pp.12, 2020, https://doi.org/10.1016/j.molmed.2020.09.004