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http://dx.doi.org/10.3345/kjp.2018.61.5.156

Diagnostic and prognostic value of proadrenomedullin in neonatal sepsis  

Fahmey, Sameh Samir (Pediatrics Department, Beni-Suef University)
Mostafa, Heba (Pediatrics Department, Beni-Suef University)
Elhafeez, Noha Abd (Clinical and Chemical Pathology Department, Beni-Suef University)
Hussain, Heba (Pediatrics Department, Beni-Suef University)
Publication Information
Clinical and Experimental Pediatrics / v.61, no.5, 2018 , pp. 156-159 More about this Journal
Abstract
Purpose: Sepsis is a major cause of neonatal morbidity and mortality. Early diagnosis is a major problem because of the lack of specific clinical signs. Therefore, a reliable diagnostic marker is needed to guide the use of antimicrobial agents. The objective of our study was to assess the value of proadrenomedullin (pro-ADM) in establishing the diagnosis and evaluating the prognosis of neonatal sepsis. Methods: This study enrolled 60 newborn infants with sepsis proven with positive blood cultures and 30 healthy neonates. Complete blood count, C-reactive protein levels, and pro-ADM levels were obtained from all neonates. Results: The pro-ADM levels were significantly higher ($14.39{\pm}0.75nmol/L$) in the sepsis group than in the control group ($3.12{\pm}0.23nmol/L$). The optimal cutoff value for pro-ADM was 4.3 nmol/L, with a sensitivity of 93.3% and a specificity of 86.7%. The pro-ADM levels were also higher in nonsurvivors (P=0.001). Conclusion: Pro-ADM can be used as a reliable biomarker for neonatal sepsis. High pro-ADM levels were associated with mortality and could be an early indicator of disease outcome.
Keywords
Neonate; Proadrenomedullin; Sepsis; Marker;
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