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  • 제27권
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  • Pages.26-34
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  • 2018
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  • 1976-4251(pISSN)
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  • 2233-4998(eISSN)
한국탄소학회 (Korean Carbon Society)
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Assembly of chemically reduced graphene oxide with folic acid functionalized with pyrene moieties and electrochemical sensing of folate receptors

  • Kwon, Binhee (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation) ;
  • Park, Jongyeap (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation) ;
  • Jeong, Woojun (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation) ;
  • Jeong, Guembi (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation) ;
  • Ryu, Hyeong Seon (Department of Organic and Nano Engineering, Hanyang University) ;
  • Paoprasert, Peerasak (Department of Chemistry, Faculty of Science and Technology, Thammasat University) ;
  • Park, Sung Young (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation) ;
  • In, Insik (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation)
  • 투고 : 2017.11.06
  • 심사 : 2017.12.11
  • 발행 : 2018.07.31
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초록

To formulate folate receptor (FR)-specific graphene-based electrochemical electrodes, a folic acid (FA) derivative attached with two pyrene molecules on the glutamate tail of FA was synthesized. The resulting pyrene-functionalized FA (FA-Py) presented the spontaneous noncovalent binding on chemically reduced graphene oxides (rGO) through an ${\pi}-{\pi}$ interaction. Ultrathin morphology, high water-resistance, and preservation of intact FR-specific pteroates from the rGO/FA-Py assembly allow this assembly to be exploited as robust and FR-specific electrochemical electrode materials. The limits of detecting rGO/FA-Py modified electrodes were found to be as low as 3.07 nM in FR concentrations in cyclic voltammetry analysis.

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참고문헌

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