Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Skin Anti-aging Effects of a Cream Containing Resveratryl Triacetate (RTA)

레스베라트릴 트라이아세테이트(RTA)를 함유한 크림의 피부 노화 완화 효과

  • Choi, Go Woon (Dermapro Skin Research Center, Dermapro Ltd.) ;
  • Jeong, Hyun Jin (Dermapro Skin Research Center, Dermapro Ltd.) ;
  • Seok, Jin Kyung (Department of Molecular Medicine, CMRI, BK21 Plus KNU, School of Medicine, Kyungpook National University) ;
  • Baek, Ji Hwoon (Dermapro Skin Research Center, Dermapro Ltd.) ;
  • Kim, Young Mi (Ruby Crown Co., Ltd.) ;
  • Boo, Yong Chool (Department of Molecular Medicine, CMRI, BK21 Plus KNU, School of Medicine, Kyungpook National University)
  • 최고운 ((주)더마프로 피부과학연구소) ;
  • 정현진 ((주)더마프로 피부과학연구소) ;
  • 석진경 (경북대학교 의과대학 분자의학교실 세포기질연구소) ;
  • 백지훈 ((주)더마프로 피부과학연구소) ;
  • 김영미 ((주)루비크라운) ;
  • 부용출 (경북대학교 의과대학 분자의학교실 세포기질연구소)
  • Received : 2018.04.12
  • Accepted : 2018.05.21
  • Published : 2018.06.30
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Abstract

Skin aging degree can be objectively measured using the instrumental analysis. The purpose of this study was to evaluate the anti-aging effects of a cream containing 8000 PPM of resveratryl triacetate (RTA) in the human skin test. Twenty female subjects were given test products twice a day for 8 weeks on the face, and wrinkles, sagging, elasticity, dermis denseness, moisture and brightness were measured every 4 weeks by instrument analysis. After 4 and 8 week-use of the test product, total wrinkle area decreased (5.12%, 4.86%), total wrinkle volume decreased (10.53%, 8.41%), sagging decreased (4.69%, 5.91%), elasticity increased (2.84%, 3.98%), dermis denseness increased (15.65%, 20.80%), water content increased (5.83%, 7.37%), lightness ($L^*$ value) increased (0.79%, 1.07%), and individual typology angle ($ITA^{\circ}$) increased (5.43%, 4.95%)compared with the baseline values before treatments, and all these changes were statistically significant (p < 0.05). No adverse skin reactions were observed in all participants during the study period. This study supports the anti-aging effects of the test product.

피부 노화의 정도는 기기 분석을 통해 객관적으로 측정 할 수 있다. 본 연구의 목적은 인체 적용 시험을 통해 8000 PPM의 레스베라트릴 트라이아세테이트(RTA)를 함유한 크림의 피부 노화 완화 효과를 평가하는 것이다. 여성 피험자 20명에게 시험 제품을 얼굴에 매일 2회 8주 동안 바르고, 4주마다 기기 분석을 통해 주름, 처짐, 탄력, 진피치밀도, 수분 및 밝기 등을 측정하였다. 시험 제품을 4 주 및 8 주 동안 사용한 결과 총 주름면적이 감소하고(5.12%, 4.86%), 총 주름 용적이 감소하고(10.53%, 8.41%), 탄력성이 증가하고(2.84%, 3.98%), 진피치밀도가 증가하고(15.65%, 20.80%), 수분이 증가하고(5.83%, 7.37%), 밝기($L^*$ 값)가 증가하고(0.79%, 1.07%), 피부색(individual typology angle, $ITA^{\circ}$)이 밝아졌으며(5.43%, 4.95%), 이들 변화는 통계적으로 유의하였다(p < 0.05). 시험 기간 동안 모든 참가자에게서 부정적인 피부 반응이 관찰되지 않았다. 본 연구는 시험 제품의 피부 노화 완화 효과를 뒷받침한다.

Keywords

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