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http://dx.doi.org/10.15230/SCSK.2018.44.2.161

Skin Anti-aging Effects of a Cream Containing Resveratryl Triacetate (RTA)  

Choi, Go Woon (Dermapro Skin Research Center, Dermapro Ltd.)
Jeong, Hyun Jin (Dermapro Skin Research Center, Dermapro Ltd.)
Seok, Jin Kyung (Department of Molecular Medicine, CMRI, BK21 Plus KNU, School of Medicine, Kyungpook National University)
Baek, Ji Hwoon (Dermapro Skin Research Center, Dermapro Ltd.)
Kim, Young Mi (Ruby Crown Co., Ltd.)
Boo, Yong Chool (Department of Molecular Medicine, CMRI, BK21 Plus KNU, School of Medicine, Kyungpook National University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.44, no.2, 2018 , pp. 161-170 More about this Journal
Abstract
Skin aging degree can be objectively measured using the instrumental analysis. The purpose of this study was to evaluate the anti-aging effects of a cream containing 8000 PPM of resveratryl triacetate (RTA) in the human skin test. Twenty female subjects were given test products twice a day for 8 weeks on the face, and wrinkles, sagging, elasticity, dermis denseness, moisture and brightness were measured every 4 weeks by instrument analysis. After 4 and 8 week-use of the test product, total wrinkle area decreased (5.12%, 4.86%), total wrinkle volume decreased (10.53%, 8.41%), sagging decreased (4.69%, 5.91%), elasticity increased (2.84%, 3.98%), dermis denseness increased (15.65%, 20.80%), water content increased (5.83%, 7.37%), lightness ($L^*$ value) increased (0.79%, 1.07%), and individual typology angle ($ITA^{\circ}$) increased (5.43%, 4.95%)compared with the baseline values before treatments, and all these changes were statistically significant (p < 0.05). No adverse skin reactions were observed in all participants during the study period. This study supports the anti-aging effects of the test product.
Keywords
resveratrol; resveratryl triacetate; anti-aging effect; human skin; cream;
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1 N. Saito, T. Nishijima, T. Fujimura, S. Moriwaki, and Y. Takema, Development of a new evaluation method for cheek sagging using a Moire 3D analysis system, Skin Res. Technol., 14(3), 287 (2008).   DOI
2 H. S. Ryu, Y. H. Joo, S. O. Kim, K. C. Park, and S. W. Youn, Influence of age and regional differences on skin elasticity as measured by the Cutometer, Skin Res. Technol., 14(3), 354 (2008).   DOI
3 H. J. Hahn, H. J. Jung, M. C. Schrammek-Drusios, S. N. Lee, J. H. Kim, S. B. Kwon, I. S. An, S. An, and K. J. Ahn, Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin, Exp. Ther. Med., 12(2), 1171 (2016).   DOI
4 A. Taub, V. Bucay, G. Keller, J. Williams, and D. Mehregan, Multi-center, double-blind, vehicle-controlled clinical trial of an alpha and beta defensin-containing anti-aging skin care regimen with clinical, histopathologic, immunohistochemical, photographic, and ultrasound evaluation, J. Drugs Dermatol., 17(4), 426 (2018).
5 H. Tagami, M. Ohi, K. Iwatsuki, Y. Kanamaru, M. Yamada, and B. Ichijo, Evaluation of the skin surface hydration in vivo by electrical measurement, J. Invest. Dermatol., 75(6), 500 (1980).   DOI
6 G. E. Pierard, EEMCO guidance for the assessment of skin colour, J. Eur. Acad. Dermatol. Venereol., 10(1), 1 (1998).   DOI
7 Y. K. Seo, S. J. Kim, Y. C. Boo, J. H. Baek, S. H. Lee, and J. S. Koh, Effects of p-coumaric acid on erythema and pigmentation of human skin exposed to ultraviolet radiation, Clin. Exp. Dermatol., 36(3), 260 (2011).   DOI
8 M. Ramos-e-Silva, L. R. Celem, S. Ramos-e-Silva, and A. P. Fucci-da-Costa, Anti-aging cosmetics: facts and controversies, Clin. Dermatol., 31(6), 750 (2013).   DOI
9 R. Honigman and D. J. Castle, Aging and cosmetic enhancement, Clin. Interv Aging. 1(2), 115 (2006).   DOI
10 R. Ganceviciene, A. I. Liakou, A. Theodoridis, E. Makrantonaki, and C. C. Zouboulis, Skin anti-aging strategies, Dermatoendocrinol., 4(3), 308 (2012).   DOI
11 Y. R. Helfrich, D. L. Sachs, and J. J. Voorhees, Overview of skin aging and photoaging, Dermatol. Nurs., 20(3), 177 (2008).
12 K. P. Wilhelm, A. B. Cua, and H. I. Maibach, Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content, Arch. Dermatol., 127(12), 1806 (1991).   DOI
13 K. Tsukahara, K. Sugata, O. Osanai, A. Ohuchi, Y. Miyauchi, M. Takizawa, M. Hotta, and T. Kitahara, Comparison of age-related changes in facial wrinkles and sagging in the skin of Japanese, Chinese and Thai women, J. Dermatol. Sci., 47(1), 19 (2007).   DOI
14 V. Karuppagounder, S. Arumugam, R. A. Thandavarayan, V. Pitchaimani, R. Sreedhar, R. Afrin, M. Harima, H. Suzuki, M. Nomoto, S. Miyashita, K. Suzuki, and K. Watanabe, Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice, Int. Immunopharmacol., 23(2), 617 (2014).   DOI
15 M. Engelke, J. M. Jensen, S. Ekanayake-Mudiyanselage, and E. Proksch, Effects of xerosis and ageing on epidermal proliferation and differentiation, Br. J. Dermatol., 137(2), 219 (1997).   DOI
16 J. P. Ortonne, Pigmentary changes of the ageing skin, Br. J. Dermatol., 122(Suppl 35), 21 (1990).
17 P. Farris, J. Krutmann, Y. H. Li, D. McDaniel, and Y. Krol, Resveratrol: a unique antioxidant offering a multi-mechanistic approach for treating aging skin, J. Drugs Dermatol., 12(12), 1389 (2013).
18 R. Yutani, R. Teraoka, and S. Kitagawa, Microemulsion using polyoxyethylene sorbitan trioleate and its usage for skin delivery of resveratrol to protect skin against UV-induced damage, Chem. Pharm. Bull. (Tokyo), 63(9), 741 (2015).   DOI
19 G. Fabbrocini, S. Staibano, G. De Rosa, V. Battimiello, N. Fardella, G. Ilardi, M. I. La Rotonda, A. Longobardi, M. Mazzella, M. Siano, F. Pastore, V. De Vita, M. L. Vecchione, and F. Ayala, Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study, Am. J. Clin. Dermatol., 12(2), 133 (2011).   DOI
20 S. Caglayan Sozmen, M. Karaman, S. Cilaker Micili, S. Isik, Z. Arikan Ayyildiz, A. Bagriyanik, N. Uzuner, and O. Karaman, Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium, Peer J., 4, 1 (2016).
21 J. Park, and Y. C. Boo, Isolation of resveratrol from vitis viniferae caulis and its potent inhibition of human tyrosinase, Evid. Based Complement. Alternat. Med., 2013, 1 (2013).
22 C. B. Lin, L. Babiarz, F. Liebel, E. Roydon Price, M. Kizoulis, G. J. Gendimenico, D. E. Fisher, and M. Seiberg, Modulation of microphthalmia-associated transcription factor gene expression alters skin pigmentation, J. Invest. Dermatol., 119(6), 1330 (2002).   DOI
23 R. A. Baxter, Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation, J. Cosmet. Dermatol., 7(1), 2 (2008).   DOI
24 P. M. Friedman, G. R. Skover, G. Payonk, A. N. Kauvar, and R. G. Geronemus, 3D in-vivo optical skin imaging for topographical quantitative assessment of non-ablative laser technology, Dermatol. Surg., 28(3), 199 (2002).   DOI
25 J. Park, J. H. Park, H. J. Suh, I. C. Lee, J. Koh, and Y. C. Boo, Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis, Arch. Dermatol. Res., 306(5), 475 (2014).   DOI
26 J. H. Ryu, J. K. Seok, S. M. An, J. H. Baek, J. S. Koh, and Y. C. Boo, A study of the human skin-whitening effects of resveratryl triacetate, Arch. Dermatol. Res., 307(3), 239 (2015).   DOI
27 Y. C. Boo, Clinical evaluation of skin whitening effect of a cream containing resveratryl triacetate, Fragrance J. Korea, 2016(3), 72 (2016).