Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
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Fractional Anisotropy of Diffuse Tensor Imaging of Normal Subjects in the Regions of the Brain White Matter According to Age and Body Mass Index (BMI)

연령과 체질량지수(BMI)에 따른 뇌 백질 부위의 정상인 확산텐서영상 비등방도에 대한 연구

  • Jeong, Jae Beom (Graduate School of Health Sciences, Busan Catholic University) ;
  • Kwak, Jong Hyeok (Department of Radiology, Pusan National University Yang San hospital) ;
  • Kim, Dong Hyeon (Graduate School of Health Sciences, Busan Catholic University)
  • 정재범 (부산가톨릭대학교 보건과학대학원) ;
  • 곽종혁 (양산부산대학교병원 영상의학과) ;
  • 김동현 (부산가톨릭대학교 보건과학대학원)
  • Received : 2018.03.19
  • Accepted : 2018.04.30
  • Published : 2018.04.30
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Abstract

Diffusion tensor images were obtained to investigate the damage of brain white matter in non-smokers and an adequate drinking group (less than 10 points) selected by scores of the Korean versions of alcohol use disorders identification test questionnaire. Factional anisotropy (FA) values, according to the variables of age and body mass index (BMI), were not statistically significant in all regions of the brain white matter after measurement of factional anisotropy (FA) values by the tract-based spatial statics (TBSS) method. In other words, age and body mass index (BMI) do not significantly affect the microstructural changes of the brain white matter.

비흡연자와 한국형 알코올 선별 검사법 (AUDIT-K)설문지 척도점수에 따라 적정음주군(10점 이하)을 연구대상으로 하여 뇌 백질의 손상 유무를 파악 할 수 있는 확산텐서영상을 검사하고 영상을 획득 한 후 Tract-Based Spatial Statics(TBSS)방법으로 뇌 백질 부위의 신경섬유로의 비등방도 FA(fractional anisotropy)값을 측정 분석한 결과 연령과 체질량지수(BMI)의 변인에 따른 뇌 백질 모든 영역에서 FA값은 통계적으로 유의하지 않았으며 본 연구의 결과 값으로 추측하자면 즉, 연령과 체질량지수(BMI)는 뇌 백질의 미세구조성 변화에 크게 영향을 미치지는 않는다고 할 수 있다.

Keywords

References

  1. Mc Creary AC, Jones CA. "Antipsychotic medication: the potential role of 5-HT (1A) receptor agonism", Pharm Des, No. 16, pp.516-521, 2010.
  2. H. J. Kim, "Age-related changes of fiber tracts in normal brain measured by diffusion tensor MR imaging", Department of Diagnostic Radiology, Graduate School Cungnam National University Daejeon, Korea, 2006.
  3. Sullivan E.V. Adalsteinsson E, "Equivalent disruption of regional white matter micro structure in aging healthy men and women", Neuro-Report, No. 12, pp. 99-104, 2001.
  4. Peters A, Morrison J. H, Rosene DL, "Are neurons lost from the primate cerebral cortex during normal aging?", Cereb. Cortex, No. 8, pp.295-300, 1998.
  5. Beaulieu C, "The basis of anisotropic water diffusion in the nervous system-a technical review", NMR in Biomedicine, Vol. 15, No. 7-8, pp.435-455, 2002. https://doi.org/10.1002/nbm.782
  6. http://fsl.fmrib.ox.ac.uk/fsl
  7. Neil JJ, Shiran SI, Mckinstry RC, "Normal brain in human newborns: Apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MRI", Radiology, No. 209, pp.57-66, 1998. https://doi.org/10.1148/radiology.209.1.9769812
  8. S. M. Smith, M. Jenkinson, "Tract-based spatial statistics : Voxel wise analysis of multi-subject diffusion data", NeuroImage, Vol. 31, No. 4, pp.1487-1505, 2006. https://doi.org/10.1016/j.neuroimage.2006.02.024
  9. S. M Smith, "Fast robust automated brain extraction. Human Brain Mapping", Vol. 17, No. 3, pp.143-155, 2002. https://doi.org/10.1002/hbm.10062
  10. www.fmrib.ox.ac.uk/analysis/techrep, J.L.R. Andersson, M. Jenskinson and S. Smith. Non-linear optimisation. FMRIB technical report TR 07 JA1.
  11. M. H. Yoon, B. Y. Choe, "Evaluation of a Fractional Anisotropy Measurement of the Corpus Callosum in the Normal Adult Brain by Using Diffusion Tensor MRI", Korea Phys. Soc, No. 4, pp.1657-1665, 2009.
  12. S. E. Rose, F. Chen, J. B. Chalk, "Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging.", J. Neurol. Neurosurg. Psychiatry, No. 4, pp.528-30, 2000.
  13. I. C. Im, E. H. Goo, J. S. Lee, Evaluation of the Neural Fiber Tractography Associated with Aging in the Normal Corpus Callosum Using the Diffusion Tensor Imaging (DTI), The Korea Society of Radiology, No. 5, pp.189-194, 2001.
  14. N. S. Joo, Obesity and Risk of Demetia Korean J Fam Pract, No. 1, pp.83-84, 2011.
  15. Stephen G. Waxman, Clinical Neuroanatomy, Seoul. Beom mun education, No. 1, pp.1-423, 2013.