The Journal of Advanced Prosthodontics

  • 제10권2호
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  • Pages.147-154
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  • 2018
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  • 2005-7806(pISSN)
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  • 2005-7814(eISSN)
대한치과보철학회 (The Korean Academy of Prosthodonitics)
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Analysis of osteogenic potential on 3mol% yttria-stabilized tetragonal zirconia polycrystals and two different niobium oxide containing zirconia ceramics

  • Hein, Aung Thu (Department of Prosthodontics, School of Dentistry, Seoul National University) ;
  • Cho, Young-Dan (Department of Periodontology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University) ;
  • Jo, Ye-Hyeon (Department of Prosthodontics, School of Dentistry, Seoul National University) ;
  • Kim, Dae-Joon (Department of Advanced Materials Engineering, Sejong University) ;
  • Han, Jung-Suk (Department of Prosthodontics, School of Dentistry, Seoul National University)
  • 투고 : 2017.07.24
  • 심사 : 2017.10.30
  • 발행 : 2018.04.30
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초록

PURPOSE. This study was performed to evaluate the osteogenic potential of 3mol% yttria-stabilized tetragonal zirconia polycrystals (3Y-TZP) and niobium oxide containing Y-TZPs with specific ratios, new (Y,Nb)-TZPs, namely YN4533 and YN4533/Al20 discs. MATERIALS AND METHODS. 3Y-TZP, YN4533 and YN4533/Al20 discs (15 mm diameter and 1 mm thickness) were prepared and their average surface roughness ($R_a$) and surface topography were analyzed using 3-D confocal laser microscope (CLSM) and scanning electron microscope (SEM). Mouse pre-osteoblast MC3T3-E1 cells were seeded onto all zirconia discs and evaluated with regard to cell attachment and morphology by (CLSM), cell proliferation by PicoGreen assay, and cell differentiation by Reverse-Transcription PCR and Quantitative Real-Time PCR, and alkaline phosphatase (Alp) staining. RESULTS. The cellular morphology of MC3T3-E1 pre-osteoblasts was more stretched on a smooth surface than on a rough surface, regardless of the material. Cellular proliferation was higher on smooth surfaces, but there were no significant differences between 3Y-TZP, YN4533, and YN4533/Al20. Osteoblast differentiation patterns on YN4533 and YN4533/Al20 were similar to or slightly higher than seen in 3Y-TZP. Although there were no significant differences in bone marker gene expression (alkaline phosphatase and osteocalcin), Alp staining indicated better osteoblast differentiation on YN4533 and YN4533/Al20 compared to 3Y-TZP. CONCLUSION. Based on these results, niobium oxide containing Y-TZPs have comparable osteogenic potential to 3Y-TZP and are expected to be suitable alternative ceramics dental implant materials to titanium for aesthetically important areas.

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