Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Comparison of local reaction at injection site following intramuscular administration with three commercial atrophic rhinitis vaccines in pigs

  • Kim, Myung-Hyee (College of Veterinary Medicine, Konkuk University) ;
  • Kwon, Taeyong (College of Veterinary Medicine, Konkuk University) ;
  • Yoo, Sung J. (College of Veterinary Medicine, Konkuk University) ;
  • Seo, Sang won (Hipra Korea Inc.) ;
  • Park, Jun Woo (College of Veterinary Medicine, Konkuk University) ;
  • Lyoo, Young S. (College of Veterinary Medicine, Konkuk University)
  • Received : 2018.06.08
  • Accepted : 2018.10.25
  • Published : 2018.12.30
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Abstract

Bordetella bronchiseptica and Pasteurella multocida are two main pathogens responsible for atrophic rhinitis (AR), which causes considerable economic losses in swine industry worldwide. Commercial vaccine has been widely used to prevent the damage from AR in Korea. Adverse effects of vaccination at the injection site have been reported, which results in the numerous complaint from farms. However, data on about local reaction at the injection site remains limited. In this study, we compared the local adverse effects of three commercial vaccines following intramuscular injection. The results showed that no gross lesion was founded at the injection sites of all three vaccines. In histopathologic examination, a various level of lesions was identified. Especially, the local reaction of vaccine including saponin as an adjuvant showed the lowest level of histopathological lesions, when compared to those of oil-based and vitamin E-based vaccines. Therefore, this study would provide the information about the extent of local reaction at the injection site and help the farmer to select AR vaccine in order to avoid adverse reaction due to vaccination.

Keywords

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Fig. 1. Histopathology of local reaction at injection sites following three different atrophic rhinitis vaccines and PBS. DPV: days of post-vaccination.

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Fig. 2. Comparison of histopathological scores of three commercial atrophic rhinitis vaccines in the injection sites. (A) 3 days of post-vaccination (DPV), (B) 7 DPV, (C) 14 DPV, (D) 28 DPV.

Table 1. Histopathological scores in the injection site

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