Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Research Trend of Biochip Sensors for Biomarkers Specific to Diagnostics of Lung Cancer Diseases

폐암 질환 진단에 활용 가능한 바이오마커 검출용 바이오칩 센서 연구 동향

  • Lee, Sang Hyuk (Department of Chemistry and Green-Nano materials Research Center, Kyungpook National University) ;
  • Goh, Eunseo (Department of Chemistry and Green-Nano materials Research Center, Kyungpook National University) ;
  • Lee, Hye Jin (Department of Chemistry and Green-Nano materials Research Center, Kyungpook National University)
  • 이상혁 (경북대학교 자연과학대학 화학과 및 청정나노소재 연구소) ;
  • 고은서 (경북대학교 자연과학대학 화학과 및 청정나노소재 연구소) ;
  • 이혜진 (경북대학교 자연과학대학 화학과 및 청정나노소재 연구소)
  • Received : 2018.11.06
  • Accepted : 2018.11.14
  • Published : 2018.12.10
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Abstract

Lung cancer has the highest death rate of any cancer diseases in Koreans. However, patients often feel difficult to recognize their disease before facing the terminal diagnosis due to the absence of any significant symptoms. Furthermore, the clear detection of an early cancer stage is usually obscure with existing diagnostic methods. For this reason, extensive research efforts have been made on introducing a wide range of biochemical diagnostic tools for the molecular level analysis of biological fluids for lung cancer diagnoses. A chip-based biosensor, one type of the analytical devices, can be a great potential for the diagnosis, which can be used without any further expensive analytical equipments nor skilled analysts. In this mini review, we highlight recent research trends on searching biomarker candidates and bio-chip sensors for lung cancer diagnosis in addition to discussing their future aspects.

한국인의 암 사망률 1위를 차지하는 폐암은 발견되기 전까지 별다른 증상이 없어 환자는 병을 쉽게 인지하지 못하고, 기존의 진단법 또한 초기단계에는 적용이 어렵다. 해결책으로서, 분자수준에서의 체액분석을 폐암진단에 도입하는 방안이 제시되고 있다. 이를 위한 분석기기 가운데 대표적으로는 칩 기반 바이오센서가 있으며, 이 센서의 큰 장점으로는 고가의 분석장비나 숙련된 분석인력이 없이도 현장에서의 진단이 가능하다는 점이다. 본 미니총설에서는 폐암 진단에 활용가능한 혈액 내 바이오마커와 바이오칩 센서의 연구현황을 소개하고 이들의 발전가능성에 대해 논의하고자 한다.

Keywords

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Figure 1. Schematics showing some of representative biochip-based sensing platforms for biomarkers for lung cancer diagnostics.

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Figure 2. (A) Schematics showing electrochemical immunosensor for ENO1 using a PEG modified carbon electrode surface[12]. (B) Real-time SPR analysis of AAT and Tau 381 proteins using mixed antibodies immobilized on a single gold chip surface[48]. (A) and (B) are reprinted with permission from refs.[12,48], respectively (Copyright American Chemical Society 2010 and 2016, respectively).

Table 1. Some of Representative Genetic and Protein Biomarker Molecules Found in Blood for Lung Cancer Disease

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Table 2. Various Biochip Sensing Technologies Developed for a Wide Range of Lung Cancer Biomarkers

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