대한한의학회지 (The Journal of Korean Medicine)

  • 제38권1호
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  • Pages.93-111
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  • 2017
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  • 1010-0695(pISSN)
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  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
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급성기관지염의 약물중재 임상시험에 대한 체계적 문헌 고찰: 임상시험 가이드라인 개발을 위한 예비연구

A Systemic Review of Clinical Trials Using Medication for Acute Bronchitis: A Pre-study on the Development of Traditional Korean Medicine Clinical Practice Guideline

  • 유이란 (대전대학교 한의과대학 내과학교실) ;
  • 박소정 (대전대학교 한의과대학 내과학교실) ;
  • 이은정 (대전대학교 한의과대학 한방재활의학교실) ;
  • 전주현 (대전대학교 한의과대학 침구의학교실) ;
  • 정인철 (대전대학교 한의과대학 신경정신과학교실) ;
  • 박양춘 (대전대학교 한의과대학 내과학교실)
  • Lyu, YeeRan (Department of Internal Medicine, College of Korean Medicine, Daejeon University) ;
  • Park, So jung (Department of Internal Medicine, College of Korean Medicine, Daejeon University) ;
  • Lee, Eun Jung (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Daejeon University) ;
  • Jeon, Ju Hyun (Department of acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University) ;
  • Jung, In Chul (Department of Neuropsychology, College of Korean Medicine, Daejeon University) ;
  • Park, Yang Chun (Department of Internal Medicine, College of Korean Medicine, Daejeon University)
  • 투고 : 2017.03.09
  • 심사 : 2017.03.24
  • 발행 : 2017.03.31
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초록

Objectives: The aim of this study is to make evidence-based data for developing a traditional Korean medicine clinical practice guideline for acute bronchitis. Methods: We searched 3 international databases(PubMed, EMBASE, CENTRAL) and 7 domestic databases (KoreaMed, Kmbase, NDSL, KISS, KISTI, OASIS, KoreaTK) to identify randomized controlled trials (RCTs) of acute bronchitis using medicine in recent 10 years. The chosen trials were analyzed by their study design, age range, intervention group, control group, primary and second outcome measure, inclusion and exclusion of participants and adverse events. Results: 15 RCTs are finally included in this study and most of their medications are herbal medicine. For diagnosis and outcome measure of acute bronchitis, Bronchitis Severity Score(BSS) was mostly used. Other measurements eligible are coughing fits, quality of life scale, sputum viscosity, change of individual symptoms and patient's satisfaction. Test duration was for average 7days and safety assessment was held by recording adverse events. Except for anti-inflammatory and antibiotic trials, all medications are found to be effective and well-tolerated. General risk of bias of chosen trials is evaluated low. Conclusions: A well designed clinical trials for traditional Korean medicine of acute bronchitis is needed and this study is expected to make it available.

키워드

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피인용 문헌

  1. Efficacy and safety of GHX02 in the treatment of acute bronchitis: protocol of a phase II, double-blind, randomised placebo-controlled trial vol.8, pp.5, 2017, https://doi.org/10.1136/bmjopen-2017-019897