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http://dx.doi.org/10.13048/jkm.17009

A Systemic Review of Clinical Trials Using Medication for Acute Bronchitis: A Pre-study on the Development of Traditional Korean Medicine Clinical Practice Guideline  

Lyu, YeeRan (Department of Internal Medicine, College of Korean Medicine, Daejeon University)
Park, So jung (Department of Internal Medicine, College of Korean Medicine, Daejeon University)
Lee, Eun Jung (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Daejeon University)
Jeon, Ju Hyun (Department of acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University)
Jung, In Chul (Department of Neuropsychology, College of Korean Medicine, Daejeon University)
Park, Yang Chun (Department of Internal Medicine, College of Korean Medicine, Daejeon University)
Publication Information
The Journal of Korean Medicine / v.38, no.1, 2017 , pp. 93-111 More about this Journal
Abstract
Objectives: The aim of this study is to make evidence-based data for developing a traditional Korean medicine clinical practice guideline for acute bronchitis. Methods: We searched 3 international databases(PubMed, EMBASE, CENTRAL) and 7 domestic databases (KoreaMed, Kmbase, NDSL, KISS, KISTI, OASIS, KoreaTK) to identify randomized controlled trials (RCTs) of acute bronchitis using medicine in recent 10 years. The chosen trials were analyzed by their study design, age range, intervention group, control group, primary and second outcome measure, inclusion and exclusion of participants and adverse events. Results: 15 RCTs are finally included in this study and most of their medications are herbal medicine. For diagnosis and outcome measure of acute bronchitis, Bronchitis Severity Score(BSS) was mostly used. Other measurements eligible are coughing fits, quality of life scale, sputum viscosity, change of individual symptoms and patient's satisfaction. Test duration was for average 7days and safety assessment was held by recording adverse events. Except for anti-inflammatory and antibiotic trials, all medications are found to be effective and well-tolerated. General risk of bias of chosen trials is evaluated low. Conclusions: A well designed clinical trials for traditional Korean medicine of acute bronchitis is needed and this study is expected to make it available.
Keywords
acute bronchitis; clinical trials; clinical practice guideline;
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1 2016 Statistical Indicator of Medical Expenses. Health Insurance Review & Assessment service. 2017:1-16.
2 Mudarri DH. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US. Journal of Environmental and Public Health. 2016;2016:2386596.
3 Eom SJ. Essentials of Primary Care: Respiratory: The most common disease of Koreans, Acute bronchitis. The Korean Association of International Medicine Sping Conference Collection. 2016; 2016:122-5.
4 Albert RH. Diagnosis and treatment of acute bronchitis. Am Fam Physician. 2010;82(11): 1345-50.
5 Nduba VN, Mwachari CW, Magaret AS, Park DR, Kigo A, Hooton TM, Cohen CR. Placebo found equivalent to amoxicillin for treatment of acute bronchitis in Nairobi, Kenya: a triple blind, randomised, equivalence trial. Thorax 63.11. 2008:999-1005.   DOI
6 Schulz V. Liquid herbal drug preparation from the root of Pelargonium sidoides is effective against acute bronchitis: results of a double-blind study with 124 patients. Phytomedicine 14. 2007:74-75.   DOI
7 Smith SM, Fahey T, Smucny J, Becker LA. Antibiotics for acute bronchitis. Cochrane Database Syst Rev. 2014;3:CD000245.
8 Wenzel RP, Fowler AA. 3rd. Clinical practice. Acute bronchitis. N Engl J Med. 2006;355(20): 2125-2130.   DOI
9 Cough Guideline. The Korean Academy of Tuberculosis and Respiratory Diseases. 2014; 26-34.
10 Dempsey PP, Businger AC, Whaley LE, Gagne JJ, Linder JA. Primary care clinicians' perceptions about antibiotic prescribing for acute bronchitis: a qualitative study. BMC family practice. 2014;15(1):194.   DOI
11 The Korean Academy of Tuberculosis and Respiratory Diseases. Respiratory Diseases. 3rd rev. ed. Soeul:Koonja publishing INC. 2007: 695-703.
12 Zanasi A, Mazzolini M, Tursi F, Morselli-Labate AM, Paccapelo A, Lecchi M. Homeopathic medicine for acute cough in upper respiratory tract infections and acute bronchitis: A randomized, double-blind, placebo-controlled trial. Pulmonary pharmacology & therapeutics 27.1. 2014:102-108.   DOI
13 Traditional Korean Medicine Clinical Practice Guideline -Antitussive and Protussive Therapy-. Korea Food & Drug Administration. 2006:1-21
14 Kim KI, Lee HJ, Lee BJ, Jung HJ, Jung SK, Lee JH. Analysis of Recent Clinical Studies to Establish Korean Herbal Medicine Clinical Trial Guidelines for the Common Cold. J. Int. Korean Med. 2016:37(1)109-134.
15 Kardos P, Lehrl S, Kamin W, Matthys H. Assessment of the effect of pharmacotherapy in common cold/acute bronchitis-the Bronchitis Severity Scale (BSS). Pneumologie 68.08. 2014:542-546.   DOI
16 Leconte S, Ferrant D, Dory V, Degryse J. Validated methods of cough assessment: a systematic review of the literature. Respiration 81.2 (2010):161-174.   DOI
17 Schmit KM, Coeytaux RR, Goode AP, McCrory DC, Yancy WS, Kemper AR, Sanders GD, et al. Evaluating cough assessment tools: a systematic review. CHEST Journal 144.6. 2013: 1819-1826.   DOI
18 Braman SS. Chronic cough due to acute bronchitis: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(suppl 1):95S-103S.   DOI
19 Gonzales R. Bartlett JG, Besser RE. Cooper RJ. Hickner JM. Hoffman JR. Sande MA. Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: background. Annals of Internal Medicine, 2001, 134.6, 521-529.   DOI
20 Tackett KL, Atkins A. Evidence-based acute bronchitis therapy. Journal of pharmacy practice. 2012:0897190012460826.   DOI
21 Knutson D, Braun C. Diagnosis and management of acute bronchitis. Am Fam Physician. 2002;65(10):2039-2044.
22 Pratter MR. Cough and the common cold: ACCP evidence-based clinical practice guidelines. Chest 2006;129:72S-4S.   DOI
23 Becker LA, Hom J, Villasis-Keever M, van der Wouden JC. Beta2-agonists for acute cough or a clinical diagnosis of acute bronchitis. Cochrane Database Syst. Rev. 2015.
24 Jiang L, Li K, Wu T. Chinese medicinal herbs for acute bronchitis. The Cochrane Library. 2012.
25 Higgins JPT. Altman DG, Gotzsche PC, Juni P, Moher D. Oxman AD, Sterne JA et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. Bmj 343 (2011): d5928.   DOI
26 Yousaf N, Lee KK, Jayaraman B, Pavord ID, Birring SS. The assessment of quality of life in acute cough with the Leicester Cough Questionnaire (LCQ-acute). Cough 7.1. 2011:4.   DOI
27 Han JM, Jung IC, Kang W, Kim SS, Yeo Y, Park YC. Reliability and validity of leicester cough questionnaire Korean version. Chronic respiratory disease 11.3. 2014:147-152.   DOI
28 Higgins JPT, Altman DG, Sterne JAC. Chapter 8: Assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1. 0 [updated March 2011]. The Cochrane Collaboration. 2011.
29 Kinkade S, Natalie AL. Acute Bronchitis. American Family Physician 94.7. 2016.
30 Lehrl S, Matthys H, Kamin W, Kardos P. The BSS-a valid clinical instrument to measure the severity of acute bronchitis. Pulm Respir Res 1. 2014:00016.
31 Fischer J, Dethlefsen, U. Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial. Cough. 2013:9(1);25.   DOI
32 Matthys H, Kamin W. Positioning of the Bronchitis Severity Score (BSS) for standardised use in clinical studies. Current medical research and opinion 29.10. 2013:1383-1390.   DOI
33 Cwientzek U, Bertram O, Petr A. Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomised study vs. an other ivy leaves extract. Phytomedicine 18.13. 2011:1105-1109.   DOI
34 Ding H, Yang Mj, Lv B, Dong Y, Li Xj, Luo Wj, et al. A Multicentered, Double-blind, Randomized Controlled Trials of Gankeshuangqing Capsule in the Treatment of Wind-heat Syndrome (Acute Upper Respiratory Infection or Acute Bronchitis). Chinese journal of evidence-based medicine. 2010;10(1):14-22.
35 Gillissen A, Wittig T, Ehmen M, Krezdorn HG, de Mey C. A multi-centre, randomised, double-blind, placebo-controlled clinical trial on the efficacy and tolerability of GeloMyrtol(R) forte in acute bronchitis. Drug research 63.01. 2013:19-27.   DOI
36 Hu SY, Li JH, Tang F, Cheng Y, Zhang YM, Zhang PP, et al. Clinical observation of Qingfei Xiaoyan Pill in treatment of lung phlegm heat syndrome in children with acute bronchitis. [Chinese]. Chinese Traditional and Herbal Drugs. 2016;47(10):1746-9.
37 Kemmerich B. Evaluation of Efficacy and Tolerability of a Fixed Combination of Dry Extracts of Thyme Herb and Primrose Root in Adults Suffering from Acute Bronchitis with Productive Cough. Arzneimittelforschung 57.09. 2007:607-615.
38 Kamin W, Maydannik VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 in patients (aged 6-18 years old) with acute bronchitis. Acta Paediatrica 99.4. 2010:537-543.   DOI
39 Kamin W, Maydannik V, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis-a randomized, double-blind, placebo-controlled multicenter trial with a herbal drug preparation from Pelargonium sidoides roots. International journal of clinical pharmacology and therapeutics 48.3. 2010: 184-191.   DOI
40 Kamin W, Ilyenko LI, Malek FA, Kieser M. Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents. Pediatrics International 54.2 2012:219-226.   DOI
41 Llor C, Moragas A, Bayona C, Morros R, Pera H, Plana-Ripoll O, Miravitlles M et al. Efficacy of anti-inflammatory or antibiotic treatment in patients with non-complicated acute bronchitis and discoloured sputum: randomised placebo controlled trial. bmj 347. 2013:f5762.   DOI
42 Matthys H, Heger M. Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, double-blind, placebo-controlled, multicentre study. Current medical research and opinion 23.2. 2007:323-331.   DOI
43 Matthys H, Lizogub VG, Malek FA, Kieser M. Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo -controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides. Current medical research and opinion 26.6. 2010:1413-1422.   DOI